雌激素受体、环氧化酶-2在卵巢癌患者中的表达及临床意义

Application Value of Estrogen Receptor and Cyclooxygenase-2 in Diagnosis and Diagnosis of Ovarian Cancer

目的:探讨雌激素受体(ER)、环氧化酶-2(COX-2)在卵巢癌患者中的表达及临床意义。方法:选取经病理手术确诊的120例患者的石蜡卵巢组织切片标本,其中卵巢癌54例,卵巢良性肿瘤66例。采用免疫组化检测ER、COX-2的表达情况。结果:ER和COX-2在卵巢癌组织中的阳性表达率明显高于良性卵巢肿瘤组织(P<0.05)。Ⅳ期卵巢癌组织中ER阳性表达率明显高于Ⅰ期(P<0.05),其余病理分期比较无差异(P>0.05);不同病理分期的COX-2阳性表达率比较无差异(P>0.05)。不同组织学分级卵巢癌组织中ER阳性表达率组组比较均无差异(P>0.05)。Ⅱ级卵巢癌组织中COX-2阳性表达率明显高于Ⅰ级(P<0.05),其余病理分级比较无统计学意义(P>0.05)。伴有转移卵巢癌组织中ER阳性表达率明显高于无转移(P<0.05);伴有转移卵巢癌组织中COX-2阳性表达率与无转移比较无统计学意义(P>0.05);伴有转移卵巢癌组织中ER、COX-2表达免疫组织化学评分法(IHS)评分均高于无转移(P<0.05)。结论:ER和COX-2在卵巢癌组织和卵巢良性肿瘤组织中的表达逐渐上调,且在卵巢癌组织的表达高于卵巢良性肿瘤组织;ER的表达与卵巢癌病理分期和转移相关,COX-2与组织学分级相关,二者对卵巢癌病情的预测具有互补性,可作为生物学指标,对卵巢癌恶性程度进行判断评估。

Objective: To investigate the application value of estrogen receptor(ER) and cox-2(cox-2) in the diagnosis and diagnosis of ovarian cancer. Methods: Paraffin embedded ovarian tissue sections of 120 patients diagnosed by pathology and operation were selected, including 54 cases of ovarian cancer and 66 cases of benign ovarian tumors. The expression of ER and cox-2 was detected by immunohistochemistry. Results: The positive expression rates of ER and cox-2 in ovarian cancer tissues were higher than those in benign ovarian cancer tissues(P<0.05). Ⅳ period ER positive expression rate was higher in ovarian cancer tissue Ⅰ period(P<0.05),compared with the rest of the groups were no difference(P>0.05). There were no difference in the cox-2 positive expression rate between groups(P>0.05). Cox-2 positive expression in Ⅱ ovarian cancer tissue level rate was higher than the level Ⅰ(P<0.05), while the rest of the way were no difference(P>0.05). ER positive expression rate in tissues with metastatic ovarian cancer was higher than that without metastasis(P<0.05). The positive expression rate of cox-2 in the tissues with metastatic ovarian cancer was not difference compared with that without metastasis(P>0.05);The expression of ER and COX-2 in ovarian cancer with metastasis and immunohistochemical score(IHS) were higher than those without metastasis(P<0.05). Conclusion: The expression of ER and COX-2 in ovarian cancer tissue and benign ovarian tumor tissue was gradually up-regulated, and the expression of ER and COX-2 in ovarian cancer tissue was higher than that in benign ovarian tumor tissue. ER expression is correlated with pathological stage and metastasis of ovarian cancer, and COX-2expression is correlated with histological grade of ovarian cancer. The prediction of ovarian cancer disease and COX-2 expression are complementary, which can be used as biological indicators to judge and evaluate the degree of malignancy of ovarian cancer.