摘要
The coronavirus disease 2019 (COVID-19) pandemic has been an unmitigated disaster for society and the economy worldwide. However, much remains unknown about the pathogenesis of, treatment methods for, and preventive measures against COVID-19. Single-cell sequencing is a novel sequencing technology whose use has recently become prevalent in various life-science fields. This high-resolution technology is being used to analyze the COVID-19 pandemic at a single-cell level. In this review, we summarize the application of single-cell sequencing technology to the field of COVID-19-related research, including the biology of severe acute respiratory syndrome coronavirus 2, clinical concerns associated with COVID-19, neutralizing antibody screening, and vaccine development. We also address challenges to, and improvements in, existing single-cell research related to COVID-19.
基金
This work was supported by grants to JP from the National Science Fund for Distinguished Young Scholars(No.81625002)
the National Natural Science Foundation of China(Nos.81930007,81470389,81500221,and 81800307)
the Shanghai Outstanding Academic Leaders Program(No.18XD1402400)
Innovative research team of high-level local universities in Shanghai and Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support(No.20152209).
