β-磷酸三钙联合载药治疗骨缺损的研究进展

Progress of drug-loaded β-tricalcium phosphate in the treatment of bone defects

由创伤、感染、肿瘤等因素引起的骨缺损是骨科临床的棘手问题, 促进骨再生与修复是治疗的关键点和难点。对于大段骨缺损, 除自体骨移植外, 常需要采用人工骨材料。β-磷酸三钙具有良好的生物相容性、骨传导和骨诱导性能, 且因其载药性能较优, 被深入研究并显示出了广阔的应用前景。本文针对β-磷酸三钙复合材料负载不同药物在创伤、感染、肿瘤性骨缺损治疗中的最新研究进展进行综述。

Bone defects caused by trauma,infection,tumor and other factors is a thorny problem in orthopedic clinic,and promoting bone repair and regeneration is the key and difficult point of treatment.In addition to autologous bone grafting,artificial bone materials are often used for large bone defects.β-tricalcium phosphate has good biocompatibility,bone conduction and bone induction properties,and has been studied deeply because of its excellent drug delivery performance and has shown broad application prospects.In this paper,the author will summarize the research progress ofβ-tricalcium phosphate composites loaded with different drugs in the treatment of bone defects caused by trauma,infection and tumor.