Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages

Periodontitis is a chronic infectious disease characterized by plaque biofilm as its main pathogenic factor;its clinical manifestations include gingival inflammation,alveolar bone resorption,attachment loss,and periodontal pocket formation,all of which eventually lead to tooth loss and seriously affect the quality of life of patients[1].This illness has a close relationship with blood sugar levels in patients with diabetes and is one of the most important complications of diabetes[2].Macrophages are an important part of host immune responses and exhibit powerful functions of identifying,phagocytizing,and removing bacteria;macrophage polarization is involved in the pathogenesis of periodontitis[3].