事件相关电位区分单双相抑郁及其疗效预测的研究进展

Research progress of event-related potential in distinguishing unipolar and bipolar depression and treatment outcome prediction

双相抑郁在临床中常被误诊为单相抑郁,且误诊率较高,只有约20%的双相抑郁患者能在第1年被明确诊断,大部分患者需要首次发作后的7~10年才能被明确诊断。目前,对两者的鉴别仍然主要依靠临床相关症状和特征。现对事件相关电位在单、双相抑郁的区别以及对其疗效预测方面进行综述,以找到能指导临床区分和预测两种疾病的客观指标。

In clinical practice,bipolar depression is often misdiagnosed as unipolar depression,and the misdiagnosis rate is high.Only about 20%of bipolar depression patients can be definitive diagnosed in the first year,and most patients need 7 to 10 years to be diagnosed after the first episode.Now the differentiation between two affective disorders is still mainly based on clinical symptoms and characteristics.This paper reviews the difference between unipolar and bipolar depression and the prediction of its curative effect through eventrelated potential,hoping to find an objective index that can guide the clinical differentiation and prediction of the two diseases.