晚发性系统性红斑狼疮的临床特征与诊疗进展

Research progress on clinical features,diagnosis and treatment of late-onset systemic lupus erythematosus

系统性红斑狼疮(SLE)是一种病因及发病机制尚不明确的自身免疫性疾病,其特点为多器官受累及自身抗体的产生.晚发性系统性红斑狼疮(LSLE)则是指患者初发时年龄≥50岁,临床表现具有异质性,典型皮损少见,靶器官受累较少,疾病活动度较低而累积损伤程度较高,并发症发生率和死亡率较高,其免疫学指标同样具有异质性,因此诊断此病较为困难.由于老年患者自身的生理状况与疾病特点使其治疗与SLE治疗稍有不同.对LSLE的临床特征及其诊断与治疗进行综述,有助于正确的诊断与治疗.

Systemic lupus erythematosus(SLE)is an autoimmune disease with unknown etiology and pathogenesis,and is characterized by multiple organ involvement and the production of autoantibodies.Late-onset SLE means that clinical symptoms first occur after 50 years of age,often without typical skin lesions and implicating fewer target organs.It exhibits low disease activity,a high degree of cumulative damage,high rates of comorbidity and mortality,and abnormal immunological profiles,which make its diagnosis difficult.Due to the physiological state and disease characteristics in the elderly,the treatment is slightly different from that for SLE.This article reviews the clinical features,diagnosis and treatment of late-onset SLE to provide a basis for accurate diagnosis and treatment.