营养不良性口炎与维生素B12和叶酸相关性的神经网络分析

Neural network analysis of the correlation between malnutrition-induced stomatitis and vitamin B12 and folic acid

目的通过神经网络分析方法搭建模型以研究不同程度维生素B12、叶酸水平缺乏与营养不良性口炎的关系。方法分别收集30例健康志愿者(对照组)和30例营养不良性口炎患者(患病组),记录病损分布、受累部位的数目、临床表现等,并进行严重程度分级,同时检测两组外周血维生素B12及叶酸水平。采用SPSS软件对营养不良性口炎患者及健康志愿者外周血维生素B12及叶酸水平进行相关性分析,MATLAB软件包对数据进行神经网络分析。结果维生素B12、叶酸水平分别与营养不良性口炎分级显著相关,水平同时异常时与营养不良性口炎的发生及严重程度呈线性关系,根据两者相关性构建了营养不良性口炎的热力图模型。结论营养不良性口炎与维生素B12、叶酸水平异常密切相关,两者协同作用可能促进营养不良性口炎发生发展。神经网络模型构建有助于对维生素B12和叶酸中重度缺乏的患者进行针对性病因治疗,有助于临床预防营养不良性口炎。

Objective A model was built by neural network analysis to study the relationship between different degrees of vitamin B12 and folic acid deficiency and malnutrition-induced stomatitis.Methods Data from 30 healthy volunteers and 30 patients with malnutrition-induced stomatitis were collected.The distribution of lesions,the number of affected sites and clinical manifestations were recorded,and the severity was scored.The levels of vitamin B12 and folic acid in the peripheral blood of the two groups were simultaneously measured.The SPSS software was used to analyze the correlation between vitamin B12 and folic acid levels in the peripheral blood of patients with malnutrition-induced stomatitis and healthy volunteers,and the MATLAB software package was used to analyze the data via a neural network.Results The levels of vitamin B12 and folic acid significantly correlated with the grade of malnutrition-induced stomatitis.Simultaneous B12 and folic acid deficiency linearly correlated with the occurrence and severity of malnutrition-induced stomatitis.Based on this correlation,a thermogram model of malnutrition-induced stomatitis was constructed.Conclusion Malnutrition-induced stomatitis is closely related to vitamin B12 and folic acid deficiency.Their synergistic effect may promote the occurrence and development of malnutrition-induced stomatitis.The construction of the malnutrition-induced stomatitis model aids the targeted etiological treatment of patients with moderate and severe deficiency to prevent malnutrition-induced stomatitis.