经皮冠状动脉介入治疗患者血脂变异性与C反应蛋白水平的关系

Relationship between serum lipid variability and C-reactive protein level in patients who underwent elective percutaneous coronary intervention

目的 探讨择期经皮冠状动脉介入治疗(PCI)患者血脂水平的变异性与C反应蛋白(CRP)水平之间的关系。方法 选择择期PCI术后1年内在门诊接受了至少3次随访检查的4 567例患者的病历资料,随访包括常规血脂水平和炎症指标,评估血脂变异性和CRP水平之间的相关性。结果 多元线性回归结果显示,HDL-C(mean)是CRP均值升高的保护因素(t=-12.01,P<0.05),HDL-C(STDEV)是CRP均值升高的危险因素(t=7.49,P<0.05);同时,HDL-C(mean)是CRP水平变异性的保护因素(t=-11.05,P<0.05),LDL-C(mean)、HDL-C(STDEV)是CRP水平变异性的危险因素(t分别=4.34、7.12,P均<0.05)。结论 HDL-C(STDEV)是CRP平均水平和变异性的危险因素,而HDL-C(mean)是CRP平均水平和变异性的保护因素。

Objective To explore the relationship between serum lipid variability and C-reactive protein(CRP)levels in patients who underwent elective percutaneous coronary intervention(PCI). Methods A total of 4567 patients were enrolled in this study who received at least three follow-up exams in the outpatient clinic within one year after elective percutaneous coronary intervention.Follow-up assessments included routine blood work,blood lipid levels,and inflammation indicators. Results The multiple linear regression showed that the HDL-C(mean)was a protective factor for the increased average level of CRP(t=-12.01,P<0.05),the variability of HDL-C(STDEV)was a risk factor for increased averag level of CRP(t=7.49,P<0.05).Meanwhile,HDL-C(mean)was a protective factor for the variability in CRP levels(t=-11.05,P<0.05),LDL-C(mean)and HDL-C(STDEV)were both risk factors for variability in CRP levels(t=4.34,7.12,P<0.05). Conclusion HDL-C(STDEV)is a risk factor for the mean level and variability of CRP,while HDL-C(mean)is a protective factor for the mean level and variability of CRP.