肌少症自噬激活和线粒体质量控制信号途径的研究进展

Autophagy Activation and Mitochondrial Quality Control in Sarcopenia

肌少症是一种与衰老相关的疾病,是由于蛋白质合成和降解的失衡,导致骨骼肌质量和力量显著降低。在衰老过程中骨骼肌的流失是不可避免的,会对老年人的生活质量造成重大影响,也可增加老年人患其他衰老相关疾病的风险。然而,与衰老相关骨骼肌流失的潜在分子机制仍不清楚。自噬是衰老过程中清除功能障碍细胞器和受损大分子的降解途径。线粒体在骨骼肌功能中也发挥关键作用。为了维持骨骼肌质量需要关注自噬过程,并通过自噬或其他方式改善线粒体的稳态。本文总结了自噬和线粒体的质量控制在肌少症中的研究进展,以期为探讨新的治疗方案提供参考。

Sarcopenia, an age-related disease caused by the imbalance in protein synthesis and degradation, can result in significant decreases in skeletal muscle mass and strength.Skeletal muscle loss during aging is inevitable and can affect the life quality of the elderly.Moreover, it may increase the risks of other age-related diseases in the elderly.However, the underlying molecular mechanism remains unclear in age-related skeletal muscle loss.Autophagy is a degradation pathway for the removal of dysfunctional organelles and damaged macromolecules during aging.Mitochondria also play a key role in skeletal muscle function.To maintain skeletal muscle mass, we should pay attention to autophagy and improve mitochondrial homeostasis through autophagy or other means.This paper summarizes the research progress of autophagy and mitochondrial quality control in sarcopenia, aiming to provide reference for exploring new therapies.