摘要
Background and Aims:Visceral obesity is a risk factor for nonalcoholic fatty liver disease(NAFLD).We investigated sex-specific optimal cutoff values for visceral fat area(VFA)associated with lean and overweight/obese NAFLD in an Asian population.Methods:This retrospective study includ-ed 678 potential living liver donors(mean age,30.8±9.4 years;434 men and 244 women)who had undergone ab-dominal computed tomography(CT)imaging and liver bi-opsy between November 2016 and October 2017.VFA was measured using single-slice abdominal CT.NAFLD was eval-uated by liver biopsy(≥5%hepatic steatosis).Receiver op-erating characteristic curve analysis was used to determine cutoff values for VFA associated with lean(body mass index[BMI]<23 kg/m2)and overweight/obese(BMI≥23 kg/m2)NAFLD.Results:Area under the curve(AUC)values with 95%confidence intervals(CI)for VFA were 0.82(95%CI,0.75-0.88)for lean and 0.74(95%CI,0.69-0.79)for over-weight/obese men with NAFLD.The AUC values were 0.67(95%CI,0.58-0.75)for lean and 0.71(95%CI,0.62-0.80)for overweight/obese women with NAFLD.The cutoff values for VFA associated with lean NAFLD were 50.2 cm2 in men and 40.5 cm2 in women.The optimal cutoff values for VFA associated with overweight/obese NAFLD were 100.6 cm2 in men and 68.0 cm2 in women.Conclusions:Sex-specific cutoff values for VFA may be useful for identifying subjects at risk of lean and overweight/obese NAFLD.
