间隔补铁法和连续补铁法治疗儿童缺铁性贫血的临床疗效比较

Comparison of the clinical efficacy of interval iron supplementation and continuous iron supplementation in the treatment of children with iron deficiency anemia

目的探究间隔补铁法和连续补铁法治疗儿童缺铁性贫血的临床疗效。方法选取2018年1月至2019年12月本院收治的50例缺铁性贫血患儿作为研究对象,以随机数字表法分为两组,每组25例。研究组采取间隔补铁法,参照组采取连续补铁法,比较两组临床疗效、治疗前后各项指标[血清铁蛋白(SF)、血红蛋白(Hb)、红细胞计数(RBC)、血清铁(SI)]水平及不良反应发生情况。结果研究组治疗总有效率为96.00%,参照组为92.00%,两组比较差异无统计学意义。治疗前,两组SF、Hb、RBC、SI水平比较差异无统计学意义;治疗3个月后,两组SF、Hb、RBC、SI水平均高于治疗前(P<0.05),但组间比较差异无统计学意义。研究组不良反应发生率为8.00%,低于参照组的32.00%,差异有统计学意义(P<0.05)。结论间隔补铁法治疗儿童缺铁性贫血的临床疗效与连续补铁法无明显差异,但不良反应较少,治疗安全性更高,值得临床推广应用。

Objective To explore the clinical efficacy of interval iron supplementation and continuous iron supplementation in the treatment of children with iron deficiency anemia.Methods 50 children with iron deficiency anemia who were admitted to our hospital from January 2018 to De-cember 2019 were selected as the research subjects and they were divided into two groups according to random number table method,with 25 cases in each group,the study group was treated with interval iron supplementation,and the reference group was treated with continuous iron supplementa-tion.The clinical efficacy,the levels of various indicators(serum ferritin[SF],hemoglobin[Hb],red blood cell count[RBC],serum iron[SI])be-fore and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate was 96.00%in the study group and 92.00%in the reference group,and there was no significant difference between the two groups.Before treatment,there was no significant difference in SF,Hb,RBC and SI levels between the two groups.After 3 months of treatment,the levels of SF,Hb,RBC and SI in the two groups were higher than those before treatment(P<0.05),but there was no significant difference between the two groups.The in-cidence of adverse reactions in the study group was 8.00%,which was lower than 32.00%in the reference group,and the difference was statistical-ly significant(P<0.05).Conclusion The clinical efficacy of interval iron supplementation in the treatment of children with iron deficiency anemia is not significantly different from that of continuous iron supplementation,but it has fewer adverse reactions and higher safety,which is worthy of clinical application.