血清S100β蛋白水平对脑出血手术患者预后评估的临床价值

Clinical value of serum S100βprotein level in evaluating the prognosis of patients with intracerebral hemorrhage surgery

目的探究血清S100β蛋白水平对脑出血手术患者预后评估的临床价值。方法选取2019年1月至2021年6月本科收治的80例高血压脑出血采用钻孔脑内血肿清除术治疗的患者作为研究组,分别于术前、术后第1天及术后第1、2、3周检测患者血清中S100β蛋白水平,另选取同期本院体检中心40名健康体检者作为对照组,检测其血清S100β蛋白水平。比较两组血清S100β蛋白水平,分析S100β蛋白水平与血肿量、格拉斯哥昏迷指数(GCS)、日常生活活动能力(ADL)评分相关性,比较研究组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗前、治疗1 d后、治疗1周后、治疗2周后,研究组血清S100β蛋白水平均明显高于对照组,差异有统计学意义(P<0.05);治疗3周后,两组血清S100β蛋白水平比较差异无统计学意义。血肿量与血清S100β蛋白水平呈正相关(P<0.05);GCS评分与血清S100β蛋白水平呈负相关(P<0.05);ADL评分与血清S100β蛋白水平呈负相关(P<0.05)。治疗后,研究组NIHSS评分为(14.53±2.05)分,低于治疗前的(22.35±3.32)分,差异有统计学意义(P<0.05)。结论对脑出血手术患者进行血清S100β蛋白水平检查对患者进行临床治疗及预后评估具有积极意义,值得推广应用。

Objective To explore the clinical value of serum S100βprotein level in the prognosis evaluation of patients with cerebral hemorrhage surgery.Methods 80 patients with hypertensive intracerebral hemorrhage who were treated in the undergraduate course from January 2019 to June 2021 and were treated with intracerebral hematoma debridement were selected as the research group,before operation,1 d after operation and 1,2 and 3 weeks after operation,serum S100βprotein levels were detected,and 40 healthy people from the medical examination center of our hospital during the same period were selected as the control group,to detect the serum S100βprotein level.The serum S100βprotein levels of the two groups were compared,and the correlation between the S100βprotein level and the hematoma volume,Glasgow ccoma scale(GCS)score,and activities of daily living(ADL)score was analyzed,and the National Institute of Health stroke scale(NIHSS)score of the research group before and after treatment was compared.Results Before treatment,after treatment for 1 d,after treatment for 1 week,and after treatment for 2 weeks,the serum S100βprotein level of the research group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After 3 weeks of treatment,there was no significant difference in serum S100βprotein level between the two groups.The hematoma volume was positive-ly correlated with the serum S100βprotein level(P<0.05);the GCS score was negatively correlated with the serum S100βprotein level(P<0.05);the ADL score was negatively correlated with the serum S100βprotein level(P<0.05).After treatment,the NIHSS score of the research group was(14.53±2.05)scores,which was lower than(22.35±3.32)scores before treatment,and the difference was statistically significant(P<0.05).Conclusion The detection of serum S100βprotein level in patients with cerebral hemorrhage surgery has positive significance for clinical treat-ment and prognosis evaluation of patients,and it is worthy of popularization and application.