肿瘤热疗与抗肿瘤免疫的研究进展

Research Progress on Hyperthermia and Anti-Tumor Immunity

近年来,随着肿瘤综合治疗的发展,热疗已成为治疗癌症的重要手段之一。大量研究表明,肿瘤细胞的清除,一方面取决于外在的治疗手段,另一方面取决于人体自身的抗肿瘤免疫状态。热疗不仅能直接杀死肿瘤细胞,还能激活人体的免疫力从而发挥抗肿瘤作用。近年来,随着肿瘤研究的深入,肿瘤热疗与抗肿瘤免疫的机制及其在临床上的应用引起了人们的兴趣,并成为一个新的研究领域。本文将肿瘤热疗与抗肿瘤免疫之间的研究进展作一综述。

In recent years,with the development of comprehensive tumor therapy,hyperthermia has become one of the important means of cancer treatment.A large number of studies have shown that the removal of tumor cells depends on exogenous treatment methods and the body’s own anti-tumor immune status.Hyperthermia cannot only directly kill tumor cells but also activate the body’s immunity to exhibit an anti-tumor effect.In recent years,with the deepening of tumor research,hyperthermia has been able to create a type I tumor microenvironment with PD-L1 overexpression and enrichment of tumor-infiltrating lymphocytes,complementing the enhancement of immune checkpoint inhibitors.Hyperthermia combined with immunotherapy may offer a new perspective in cancer treatment.The mechanism of tumor hyperthermia and anti-tumor immunity and its clinical application have aroused great interest and become a new research field.This article reviews the relationship between tumor hyperthermia and anti-tumor immunity.