低频重复经颅磁刺激联合蒙医温针治疗肺癌化疗后失眠的临床效果观察

Clinical Study of Low Frequency Repetitive Transcranial Magnetic Stimulation Combined with Mongolian Medicine Warm Acupuncture in the Treatment of Insomnia After Chemotherapy for Lung Cancer

目的:观察低频重复经颅磁刺激(rTMS)联合蒙医温针治疗肺癌化疗后失眠的疗效。方法:选取2018年8月至2019年6月内蒙古医科大学附属人民医院肿瘤内科A区收治的肺癌化疗后失眠患者120例作为研究对象,随机分为观察组和对照组,每组60例。观察组采用低频重复经颅磁刺激(rTMS)联合温针组治疗,对照组采用温针治疗,比较2组的治疗效果。在治疗前和治疗第4周后进行多导睡眠监测(PSG)和匹兹堡睡眠质量指数量表(PSQI)测定。结果:治疗4周后,观察组患者PSQI评分低于对照组,2组比较差异有统计学意义(P<0.05),观察组睡眠质量疗效的有效率均高于对照组,2组比较差异均有统计学意义(均P<0.05);观察组实际睡眠总时间、睡眠效率均高于对照组,睡眠潜伏期、觉醒次数、快速眼球运动睡眠潜伏期均低于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:低频rTMS联合温针治疗有助于改善肺癌患者化疗后出现的失眠,提高其睡眠质量。

Objective:To investigate the clinical efficacy of low-frequency repetitive transcranial magnetic stimulation(rTMS)combined with warming acupuncture of Mongolian medicine in the treatment of sleep disorders after chemotherapy for lung cancer.Methods:A total of 120 patients with insomnia disorder who met the diagnostic criteria for chronic insomnia in the Guidelines for the Diagnosis and treatment of Insomnia Disorder in China were enrolled,and patients were divided into two groups according to the random number table method,with 60 cases in each group.The observation group received the low-frequency rTMS combined with warming acupuncture of Mongolian medicine,while the control group received thewarming acupuncture of Mongolian medicine.Polysomnography was performed and all patients were assessed by Pittsburgh Sleep Quality Index before treatment and 4 weeks after treatment.Results:At the 4th weekend of treatment,the PSQI score of the observation group was lower than that of the control group,the effective rate of it were higher than those of the control group(P<0.05).The total sleep time and sleep efficiency of it were higher than those of the control group(P<0.05),while the sleep latency,wake times and REM sleep latency were all lower than those of the control group(P<0.05).Conclusion:Low-frequency repetitive transcranial magnetic stimulation combined with warming acupuncture of Mongolian medicine may improve their sleep quality about sleep disorders after chemotherapy for lung cancer.