艾滋病合并肺结核治疗效果与CD_(4)^(+)T淋巴细胞及影像学的相关性

Correlation between therapeutic effect of AIDS complicated with tuberculosis and CD_(4)^(+)T lymphocyte and imaging

目的探究临床上艾滋病合并肺结核患者的治疗效果和CD_(4)^(+)T淋巴细胞以及影像学之间的相关性。方法在滇南中心医院2018年1月—2019年1月期间收治的艾滋病合并肺结核患者中随机选取30例作为研究组,同期单纯肺结核患者30例作为对照组,对2组患者的CD_(4)^(+)T淋巴细胞检查结果和胸部CT中所表现出的影像学特征进行对比分析。结果治疗前,研究组的CD_(4)^(+)T淋巴细胞数量低于对照组(P<0.05)。治疗后,研究组患者CD_(4)^(+)T淋巴细胞数量有所提升,对照组患者CD_(4)^(+)T淋巴细胞数量无明显变化,但研究组仍低于对照组(P<0.05)。30例AIDS合并肺结核患者中25例呈现出不典型肺结核特征,5例呈现出典型肺结核特征,在CD_(4)^(+)T淋巴细胞分布全宽方面,不典型肺结核患者主要分布于100~200个/μL的范围内,典型肺结核患者主要分布于<100个/μL的范围内。艾滋病合并肺结核患者的CT结果主要表现为不典型肺结核且具有多样性变化特点。结论艾滋病合并肺结核患者的CD_(4)^(+)T淋巴细胞数量较单纯肺结核患者低,通过系统治疗之后,CD_(4)^(+)T淋巴细胞数量显著升高,影像学检查大部分患者的临床表现为非典型肺结核疾病。

Objective To explore the relationship between therapeutic effect and CD_(4)^(+)T lymphocytes and imaging in patients with AIDS complicated with tuberculosis.Methods In the hospital from January 2018 to January 2019 AIDS tuberculosis patients admitted during the period of 30 cases were randomly selected as research group,at the same time,selecting 30 cases hospitalized during the period of pure tuberculosis patients as control group,CD_(4)^(+)T lymphocytes in patients with two groups of test results and chest CT imaging features shown in the reasonable analysis.Results Before treatment,the number of CD_(4)^(+)T lymphocytes in the study group was lower than that in the control group(P<0.05).After treatment,the number of CD_(4)^(+)T lymphocytes increased in the study group,while there was no significant change in the number of CD_(4)^(+)T lymphocytes in the control group,indicating that the difference between the groups was statistically significant(P<0.05).Through the analysis of the imaging data of the patients in the study group,it was found that among the 30 patients with AIDS complicated with tuberculosis,25 showed atypical characteristics of tuberculosis,and 5 showed typical characteristics of tuberculosis.In terms of the distribution of the full width of CD_(4)^(+)T lymphocytes,atypical tuberculosis patients mainly distributed within the range of 100-200/μL.Typical tuberculosis patients are mainly distributed in the range of<100/μL.According to the chest CT examination results of the patients,the results of AIDS patients with tuberculosis mainly showed atypical tuberculosis and the results were diverse.Conclusion The number of CD_(4)^(+)T lymphocytes in PATIENTS with AIDS complicated with tuberculosis is lower than that in patients with simple tuberculosis.After systematic treatment,the number of CD_(4)^(+)T lymphocytes is significantly increased.In imaging examination,most patients with this disease have clinical manifestations of atypical tuberculosis.