基于数据挖掘探讨胃食管反流病中医证型与用药规律分析

TCM Syndrome and Medication Rule of Gastroesophageal Reflux Disease Based on Data Mining

目的:总结治疗胃食管反流病的临床用药经验,分析遣方用药规律,为临床治疗本病提供新的思路。方法:选取2019年6月至2021年6月辽宁中医药大学附属医院收治的胃食管反流病住院治疗患者数据,根据其临床症状进行分型,采用SPSS统计软件对药物进行聚类分析和关联分析,运用Cytoscape软件绘制进行复杂网络药物分析图,归纳总结胃食管反流病的常用药、常用药对、用药规律。结果:最终纳入的204例患者中,中医证型中证频数最多的为肝胃不和证,且与肝、脾、肺、胃、肾、心密切相关。在肝胃不和证型的用药规律分析中,治疗药物多以甘、苦味为主。温药、寒药在治疗上使用频次相当,无明显偏向性。治疗的核心处方包括18味中药。结论:肝胃不和证型是胃食管反流病中分布最多的证型,核心处方主要由柴胡疏肝散、二陈汤、四君子汤等方剂加减变化组成。

Objective:To summarize the clinical medication experience and extract the medication rules for treating gastroesophageal reflux disease and provide new ideas for the clinical treatment of this disease.Methods:The data of the patients admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from June 2019 to June 2021 due to gastroesophageal reflux disease were collected.SPSS was used for cluster analysis and association analysis and Cytoscape for drawing the complex medicine network,on the basis of which the common Chinese herbal medicines,common herb pairs,and medication rules were mined.Results:Most of the 204 patients included presented the syndrome of liver-stomach disharmony,which was closely related to liver,spleen,lung,stomach,kidney,and heart.For the treatment of this syndrome,sweet or bitter herbal medicines were mainly used,and warm and cold herbal medicines showed similar frequency.The core prescription for treatment included 18 Chinese herbal medicines.Conclusion:Liver-stomach disharmony is the most common syndrome of gastroesophageal reflux disease.The core prescription used is mainly composed of modified Chaihu Shugan Powder,Erchen Decoction,and Sijunzi Decoction.