阿替普酶静脉溶栓治疗轻型急性脑梗死患者的疗效分析

Efficacy analysis of intravenous thrombolytic therapy with rt-PA in patients with mild acute cerebral infarction

目的 探究阿替普酶(rt-PA)静脉溶栓治疗轻型急性脑梗死的疗效。方法 选取2018年5月至2020年5月本院收治的60例轻型急性脑梗死患者作为研究对象,按照随机数字表法分为观察组(rt-PA静脉溶栓治疗)与对照组(阿司匹林治疗),每组30例。比较两组治疗前后氧化应激水平、美国国立卫生院神经功能缺损评分量表(NIHSS)评分、BI评分及临床疗效。结果 治疗前,两组丙二醛(MDA),超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)水平比较差异均无统计学意义;治疗后,两组MDA均低于治疗前,且观察组低于对照组(P<0.05),两组SOD及GSH-Px均高于治疗前,且观察组高于对照组(P<0.05);治疗前,两组NIHSS评分、BI评分比较差异无统计学意义;治疗后,观察组NIHSS评分低于对照组,BI评分高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为93.3%,高于对照组的70.0%,差异有统计学意义(P<0.05)。结论 rt-PA静脉溶栓治疗轻型急性脑梗死疗效确切,能明显改善患者氧化应激反应及神经缺损,有利于提升患者日常生活活动能力,值得临床推广应用。

Objective To investigate the efficacy of intravenous thrombolysis therapy with alteplase(rt-PA) in the treatment of mild acute cerebral infarction. Methods A total of 60 patients with mild acute cerebral infarction admitted to our hospital from May 2018 to May 2020 were selected as research subjects, and they were divided into observation group(rt-PA intravenous thrombolytic therapy) and control group(aspirin treatment)according to random number table method, with 30 cases in each group. The oxidative stress level, National Institute of Health stroke scale score, BI score and clinical efficacy were compared between two groups before and after treatment. Results Before treatment, there was no significant difference in the levels of malondialdehyde(MDA), superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) between the two groups;after treatment, MDA in two groups was lower than before treatment, and observation group was lower than control group(P<0.05), SOD and GSH-Px in two groups were higher than before treatment, and observation group was higher than control group(P<0.05). Before treatment, there was no statistically significant difference in NIHSS score and BI score between the two groups;after treatment, NIHSS score in the observation group was lower than that in the control group, while BI score was higher than that in the control group, the difference was statistically significant(P<0.05). The total effective rate of observation group was 93.3%, which was higher than 70.0% of control group, the difference was statistically significant(P<0.05).Conclusion rt-PA intravenous thrombolytic therapy for mild acute cerebral infarction has definite efficacy, can significantly improve the oxidative stress response and nerve defects of patients, is beneficial to improve the ability of daily living activities of patients, worthy of clinical application.