血清白细胞介素-21和血清颗粒蛋白前体与慢性阻塞性肺疾病患者呼吸功能的关系探讨

Relationship between serum interleukin-21 and progranulin and respiratory function in patients with chronic obstructive pulmonary disease

目的探究血清白细胞介素-21(IL-21)和血清颗粒蛋白前体(PGRN)与慢性阻塞性肺疾病(COPD)患者呼吸功能的关系。方法选取2018年3月至2019年3月本院收治的86例慢性阻塞性肺疾病患者作为研究对象,包括急性加重期52例(急性加重期组)、稳定期34例(稳定期组),另选取30名健康体检者作为对照组,比较3组血清IL-21、PGRN水平及肺功能指标,分析IL-21、PGRN与COPD患者呼吸功能的关系。结果急性加重期组和稳定期组IL-21、PGRN水平均高于对照组,差异有统计学意义(P<0.05);急性加重期组IL-21、PGRN水平均高于稳定期组,差异有统计学意义(P<0.05);急性加重期组、稳定期组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)均低于对照组,差异有统计学意义(P<0.05);急性加重期组FEV_(1)、FVC均低于稳定期组,差异有统计学意义(P<0.05);Pearson相关性分析显示,慢性阻塞性肺疾病患者IL-21、PGRN与FEV_(1)、FVC呈负相关,差异有统计学意义(P<0.01)。结论慢性阻塞性肺疾病患者体内血清IL-21、PGRN水平明显升高,急性加重期COPD患者体内血清IL-21、PGRN水平高于稳定期COPD患者,IL-21、PGRN与FEV_(1)、FVC等肺功能指标呈负相关。

Objective To explore the relationship between serum interleukin-21(IL-21)and serum progranulin(PGRN)and respiratory function in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 86 patients with COPD admitted to our hospital from March 2018 to March 2019 were selected as the research subjects,including 52 patients in acute exacerbation stage(acute exacerbation group)and 34 patients in stable stage(stable group).Another 30 healthy subjects were selected as the control group.The serum levels of IL-21,PGRN and pulmonary function indexes were compared among the three groups,and the relationship between IL-21,PGRN and respiratory function in COPD patients was analyzed.Results The levels of IL-21 and PGRN in the acute exacerbation group and the stable group were higher than those in the control group,and the difference was statistically significant(P<0.05);the levels of IL-21 and PGRN in the acute exacerbation group were higher than those in the stable group,and the difference was statistically significant(P<0.05);the forced expiratory volume in one second(FEV_(1))and forced vital capacity(FVC)in the acute exacerbation group and the stable group were lower than those in the control group,and the difference was statistically significant(P<0.05);the FEV_(1) and FVC of the acute exacerbation group were lower than those of the stable group,and the difference was statistically significant(P<0.05);Pearson's correlation analysis showed that IL-21 and PGRN were negatively correlated with FEV_(1) and FVC in patients with COPD,and the difference was statistically significant(P<0.01).Conclusion The levels of serum IL-21 and PGRN in patients with chronic obstructive pulmonary disease were significantly increased,and the levels of serum IL-21 and PGRN in patients with acute exacerbation COPD were higher than those in patients with stable COPD,IL-21,PGRN were negatively correlated with FEV_(1),FVC and other pulmonary function indicators.