观察卡前列素氨丁三醇治疗产后出血的疗效及对产妇凝血因子的影响

To observe the efficacy of carboprost tromethamine in the treatment of postpartum hemorrhage and its effect on maternal coagulation factors

目的 观察卡前列素氨丁三醇治疗产后出血的疗效及对产妇凝血因子的影响。方法 选取2018年6月至2020年6月本院收治的196例产后出血患者作为研究对象,采用随机数字表法分为对照组和观察组,每组98例。对照组给予宫缩素治疗,观察组采用卡前列素氨丁三醇治疗,比较两组凝血功能指标、出血量、出血时间及用药不良反应情况。结果 治疗前,两组活化部分促凝血酶原激酶(APTT)、血浆凝血酶原时间(PT)、血小板、纤维蛋白原(FIB)水平比较差异无统计学意义;治疗后,观察组血小板低于对照组,APTT、PT短于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05)。观察组术中出血量、术后2 h出血量与产后24 h出血量均少于对照组,止血时间短于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 卡前列素氨丁三醇治疗产后出血效果显著,且能有效控制患者出血量,不良反应发生率较低,值得临床推广应用。

Objective To analyze the clinical effect of carboprost tromethamine in the treatment of postpartum hemorrhage. Methods 196 cases of postpartum hemorrhage treated in our hospital from June 2018 to June 2020 were selected as the research subjects, and they were divided into control group and observation group by digital table method, with 98 cases in each group. The control group was treated with oxytocin and the observation group was treated with carboprost tromethamine. The coagulation function indexes, bleeding volume, bleeding time and adverse drug reactions were compared between the two groups. Results Before treatment, there was no significant difference in activated partial thromboplastin time(APTT), plasma prothrombin time(PT), platelets and fibrinogen(FIB) between the two groups;after treatment, the platelets in the observation group were lower than that in the control group, APTT and PT in the observation group were shorter than that in the control group, and the levels of FIB was higher than that in the control group, the difference was statistically significant(P<0.05). The amount of bleeding during operation, 2 h after operation and 24 h after delivery in the observation group were less than those in the control group, and the hemostasis time in the observation group was shorter than that in the control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Carboprost tromethamine is effective in the treatment of patients with postpartum hemorrhage, and it can effectively control the amount of bleeding, the incidence of adverse reactions is low, which is worthy of clinical application.