聚乙二醇散联合双歧杆菌四联活菌片治疗功能性便秘的效果观察

Observation on the effect of polyethylene glycol powder combined with bifidobacteria quadruple viable tablets in the treatment of functional constipation

目的 探讨聚乙二醇散联合双歧杆菌四联活菌片治疗功能性便秘的效果。方法 选取2019年1月至2020年1月于本院就诊的100例功能性便秘患者作为研究对象,采用随机数字表法分为两组,各50例。对照组给予聚乙二醇散联合莫沙比利治疗,观察组给予聚乙二醇散联合双歧杆菌四联活菌片治疗。比较两组临床疗效、临床症状积分及生命质量[便秘患者生活质量量表(PAC-QOL)评分]及安全性。结果 观察组治疗总有效率为98.00%,高于对照组的84.00%,差异有统计学意义(P<0.05)。治疗前,两组临床症状积分、PAC-QOL评分比较差异无统计学意义;治疗后,观察组粪便性状[(0.36±0.12)分]、排便持续时间[(0.31±0.12)分]、排便频率[(0.27±0.10)分]、排便费力[(2.15±0.44)分]、坠胀不尽感[(2.48±0.31)分]、饱胀[(1.56±0.22)分]评分均低于对照组,PAC-QOL评分[(17.98±2.67)分]高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义。结论 聚乙二醇散联合双歧杆菌四联活菌片治疗功能性便秘的效果优于联合莫沙比利,可有效改善患者症状与生命质量,且安全可靠。

Objective To investigate the effect of polyethylene glycol powder combined with bifidobacteria quadruple viable tablet in the treatment of functional constipation. Methods A total of 100 patients with functional constipation who visited our hospital from January 2019 to January 2020 were selected as the research subjects, and they were divided into two groups according to random number table method, with 50 cases in each group. The control group was treated with polyethylene glycol powder combined with mosapride, and the observation group was treated with polyethylene glycol powder combined with bifidobacteria quadruple viable tablets. The clinical efficacy, clinical symptom score, quality of life(Constipation Patient quality of life scale [PAC-QOL] score) and safety were compared between the two groups. Results The total effective rate of the observation group was 98.00%, which was higher than 84.00% of the control group, and the difference was statistically significant(P<0.05). Before treatment,there was no significant difference in the clinical symptom scores and PAC-QOL scores between the two groups;after treatment, the fecal characteristics of the observation group([0.36±0.12] scores), defecation duration([0.31±0.12] scores), defecation frequency([0.27±0.10] scores), defecation effort([2.15±0.44] scores), the unfinished bulge([2.48±0.31] scores) and fullness([1.56±0.22] scores) were lower than those of the control group, and the PAC-QOL score([17.98±2.67] scores) was higher than that of the control group, and the difference was statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion The effect of polyethylene glycol powder combined with bifidobacteria quadruple viable tablet in the treatment of functional constipation is better than that of mosapride, it can effectively improve the symptoms and quality of life of patients, and it is safe and reliable.