基于高分子材料的有机/无机纳米杂合体递药系统的抗肿瘤治疗研究进展

Research Progress of Organic/Inorganic Nanohybrids Drug Delivery System Based on Polymer Materials for Anti-tumor Therapy

基于高分子材料的有机/无机纳米杂合体递药系统,是将有机高分子材料与无机纳米粒子制备成用于药物递送的纳米杂合体,具有易修饰、高靶向性、良好的稳定性与生物相容性等优点。有机/无机纳米杂合体以突出的协同治疗效果备受关注,其在诊疗一体化中的应用为抗肿瘤治疗提供了新思路和新方法。对有机/无机纳米杂合体的构建策略及应用进行综述,并讨论其用于抗肿瘤治疗的优势和挑战,为有机/无机纳米杂合体的进一步应用提供参考。

Organic/inorganic nanohybrids drug delivery system based on polymer materials is a kind of nanohybrid prepared from organic polymer materials and inorganic nanoparticles for drug delivery,which show various advantages such as easy modifiability,high targetability,remarkable stability and good biocompatibility.The organic/inorganic nanohybrids have attracted much attention for their outstanding synergistic therapeutic effects,and their application in the integration of diagnosis and therapy provides new ideas and methods for anti-tumor therapy.This article reviews the preparation strategies and applications of organic/inorganic nanohybrids,and discusses their advantages and challenges in anti-tumor therapy,so as to provide reference for further application of organic/inorganic nanohybrids.