肠道微生物与子宫内膜异位症发病机制的研究进展

Advances in intestinal microorganisms and the pathogenesis of endometriosis

子宫内膜异位症(endometriosis,EMS)是一种慢性炎症性疾病,呈现雌激素依赖性。关于EMS的起源有很多学说,但发病机制目前仍未明晰。近年来,高通量测序的发展为肠道微生物与EMS之间的关系提供了新思路。对EMS患者与健康人粪便样本进行下一代测序分析比对,确定其特定的肠道微生物群组成,分析其对EMS潜在的病理生理机制的影响,从而开发出新的EMS预防和治疗策略。本篇综述重点就肠道微生物参与EMS发病机制的研究进展进行论述。

Endometriosis(EMS)is a chronic inflammatory disease that is estrogen-dependent.It was defined as endometrial tissue outside the uterus with clinical manifestations of chronic pelvic pain,abnormal menstruation and infertility.There are many theories about the origin of EMS,but the pathogenesis is still unclear.In recent years,the development of high-throughput sequencing has provided new ideas for the relationship between intestinal microorganisms and EMS.The next generation sequencing analysis and comparison of feces samples from patients with EMS and healthy persons were conducted to determine the composition of specific intestinal microflora and analyze the influence of potential pathophysiological mechanisms of EMS,so as to develop new prevention and treatment strategies for EMS.In this review,the research progress on the involvement of intestinal microorganisms in the pathogenesis of EMS was summarized.