慢性子宫内膜炎的诊断及生育相关的发病机制研究进展

Research progress in diagnosis and pathogenesis of chronic endometritis

慢性子宫内膜炎(chronic endometritis,CE)是一种局部慢性炎症性疾病,其病理特征是子宫内膜间质浆细胞浸润。CE主要的病因是微生物感染,然而,是否发生病理改变可能取决于子宫内膜免疫系统能否对微生物的感染进行适当的反应。CE能够使子宫内膜免疫环境发生变化,子宫内膜容受性严重下降,并且与女性生殖预后密切相关,是反复种植失败及复发性流产的重要原因之一。本文就CE的诊断、微生物学及免疫学研究进展进行综述,以期为今后的研究、诊断及治疗提供依据。

Chronic endometritis(CE)is a local chronic inflammatory disease characterized by the infiltration of plasma cells into the endometrial stromal area.The main cause of CE is microbial infection.However,whether pathological changes occur may depend on whether the endometrial immune system can appropriately respond to microbial infection.CE can cause changes in the immune environment of the endometrium,decrease the endometrial receptivity severely,and is closely related to female reproductive prognosis.It is one of the important reasons for repeated implantation failure and recurrent miscarriage.In this review,we summarized the advances in the diagnosis,microbiology and immunology of CE,in order to provide the basis for future research,diagnosis and treatment.