陕北膜荚黄芪中的一个新二苯基丁二酮

A new diphenyl butanedione from Astragalus membranaceus of northern Shanxi

采用硅胶和凝胶柱色谱技术,结合现代波谱学方法及其理化性质分析,从陕北膜荚黄芪(Astragalus membranaceus)醇提取物中共分离鉴定了7个化合物,分别为黄芪甲苷(1)、芒柄花素(2)、毛蕊异黄酮(3)、1-(4-羟苯基)-4-(2,4-羟苯基)-2-羟基-1,4-丁二酮(4)、反式-4-甲基肉桂酸(5)、槲皮素(6)和尿嘧啶核苷(7)。其中化合物4为新化合物,化合物5系首次从黄芪属中分得。体外抗肿瘤活性结果显示,化合物4对人肺癌细胞A549增殖有一定抑制作用,IC_(50)为11.41μmol·L^(-1)。

Seven compounds were isolated from Astragalus membranaceus of northern shaanxi by silica gel and Sephadex LH-20 column chromatographies.Their chemical structures were identified on the basis of their physical and chemical properties.These compounds were elucidated as astragaloside IV(1),formononetin(2),calycosin(3),1-(4-hydroxyphenyl)-4-(2,4-hydroxyphenyl)-2-hydroxy-1,4-but anedione(4),(E)-4-methylcinnamic acid(5),quercetin(6),and uridine(7).Compound 4 is a new compound and compound 5 was isolated from the plants of Astragalus Linn.for the first time.The results of in vitro antitumor activity assay showed that compound 4 could inhibit the proliferation of A549 with IC_(50) values of 11.41μmol·L^(-1).