基于基因多态性调整华法林治疗儿童脑静脉窦血栓形成1例

Treatment of Cerebral Venous Thrombosis in a Child with Warfarin Based on Gene Polymorphism

目的:探讨临床药师在儿童脑静脉窦血栓形成治疗中的药学监护作用,为临床合理用药提供参考。方法:回顾性分析临床药师对1例儿童脑静脉窦血栓形成治疗中的药学监护过程。结果:临床药师通过分析患儿病情、华法林基因型和国际标准化比值,协助临床医师调整华法林用药方案,患儿康复出院。结论:临床药师基于基因多态性参与患儿华法林个体化抗凝方案的制定,有利于提高药物治疗水平,确保患儿用药安全、有效。

Objective:To probe into the role of clinical pharmacists in pharmaceutical care for the treatment of a child with cerebral venous thrombosis,so as to provide reference for the rational clinical drug use.Methods:Retrospective analysis was performed on the pharmaceutical care for a child with cerebral venous thrombosis by clinical pharmacists.Results:By analyzing the disease condition,genotype of warfarin and international normalized ratio of the child,the clinical pharmacists assisted the clinicians to adjust the dose of warfarin.The child recovered and was discharged from the hospital.Conclusion:Based on genetic polymorphism,clinical pharmacists participate into the formulation of anticoagulation regimens for children with warfarin,which promote the rational clinical drug use,and further ensure the safety of drug use in children.