摘要
干细胞移植在缺血性卒中的治疗领域颇具潜力,尤以骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)研究最为广泛。研究表明,BMSCs主要以旁分泌方式发挥其功能,其释放的外泌体表现出类似BMSCs的生物活性。BMSCs外泌体作为无细胞疗法,在缺血性卒中的研究领域已取得诸多进展。文章就BMSCs外泌体治疗缺血性卒中的研究进展进行了综述。
Stem cell transplantation has great potential in the treatment of ischemic stroke,and bone marrow mesenchymal stem cells(BMSCs)are the most widely studied.Studies have shown that BMSCs mainly perform their functions in a paracrine manner,and the exosomes released by BMSCs show biological activities similar to BMSCs.As a cell-free therapy,BMSCs exosomes have made a lot of progress in the field of ischemic stroke.This article reviews the research progress of BMSCs-derived exosomes in the treatment of ischemic stroke.
作者
靳杨
蔡奕晨
张云莎
徐士欣
Jin Yang;Cai Yichen;Zhang Yunsha;Xu Shixin(School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Medical Experimental center,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)
出处
《国际脑血管病杂志》
2022年第5期369-374,共6页
International Journal of Cerebrovascular Diseases
基金
天津中医药大学中西医结合学院2020年度教师科研启动基金(ZXYKYQDLX202001)
天津市自然科学基金重点项目(19JCZDJC37100)。
关键词
卒中
脑缺血
骨髓细胞
间充质干细胞
外泌体
Stroke
Brain ischemia
Bone marrow cells
Mesenchymal stem cells
Exosomes
