炎症在颅内动脉瘤中的作用和潜在的药物治疗

Role of inflammation in intracranial aneurysms and potential drug therapy

颅内动脉瘤是一种常见的脑血管病,其破裂后致残率和病死率较高,患者通常预后不良。颅内动脉瘤主要是采取开颅手术夹闭和血管内栓塞治疗,但对直径<5 mm的未破裂动脉瘤是否需要干预尚存争议。研究表明,炎症在颅内动脉瘤的形成、进展和破裂过程中均起着重要作用。阿司匹林和他汀类药物可通过抗炎延缓颅内动脉瘤发展,并有助于降低破裂风险。文章对颅内动脉瘤的炎症机制和潜在的药物治疗进行了综述。

Intracranial aneurysm is a common cerebrovascular disease,which has a high morbidity and mortality after rupture,usually resulting in poor prognosis.Intracranial aneurysms are mainly treated by craniotomy clipping and endovascular embolization,but there is still controversy about whether the unruptured aneurysms with a diameter of<5 mm need intervention.Studies have shown that inflammation plays an important role in the formation,progression,and rupture of intracranial aneurysms.Aspirin and statins can delay the development of intracranial aneurysms and help reduce the risk of rupture through anti-inflammatory.This article reviews the inflammatory mechanism and potential drug therapy of intracranial aneurysms.