益生菌在老年人幽门螺杆菌感染根除治疗中的应用进展

Advances of probiotics in the eradication treatment of Helicobacter pylori infection in the elderly

幽门螺杆菌(H.pylori)感染可以加重老年人胃部症状及疾病负担。老年人因其生理心理特殊性,行根除H.pylori治疗存在耐受性差、依从性低、不良反应多等问题,根除H.pylori应进行获益—风险评估并遵循个体化原则。益生菌作为新兴微生物制剂,可应用于根除H.pylori治疗方案中,可能通过分泌抗菌物质、保护胃黏膜、参与免疫机制调节、抑制黏膜定植等起作用。目前研究显示,在老年人群根除H.pylori治疗时添加益生菌可以降低不良反应发生率,而对于根除率的影响仍存在争议。

Helicobacter pylori(H.pylori)infection can aggravate gastric symptoms and disease burden in the elderly.Due to their physiological and psychological peculiarities,the eradication treatment of H.pylori infection in the elderly has problems such as poor tolerance,low compliance and more adverse reactions.Benefit-risk assessment and individualized principles should be followed for H.pylori eradication in the elderly.Probiotics,the emerging microbial agents,can be used in H.pylori eradication therapy,but the mechanism is still unclear,which may act by secreting antibacterial substances,protecting gastric mucosa,participating in the regulation of immune mechanism,and inhibiting mucosal colonization.Current studies show that the addition of probiotics to H.pylori eradication therapy in the elderly population reduces the incidence of adverse effects,while the impact on eradication rate remains controversial.