环丝氨酸的热分解特性及自反应危险性研究

Thermal decomposition characteristics and self-reactiveness risk of cycloserine

环丝氨酸作为合成非典型β-内酰胺抗生素的重要中间体,被广泛应用于临床医学产业,但由于其特殊的分子结构使之运输过程中存在热不稳定性。因此,获取环丝氨酸的热分解动力学数据并确定其热危险性,以保证其安全运输势在必行。通过动态DSC获取环丝氨酸的起始分解温度、峰值温度及放热量,并通过Kissinger法获取环丝氨酸的活化能E及指前因子A。基于热动力学数据及Semenov模型预估了环丝氨酸的自加速分解温度(SADT)为69℃,并通过热积累储存试验验证。

Cycloserine is widely used in the clinical medical industry as an important intermediate in the synthesis of atypical β-lactam antibiotics, but its special molecular structure makes it thermally unstable during transportation.Therefore, it was imperative to obtain the thermal decomposition kinetic data of cycloserine and determine its thermal hazard to ensure its safe transportation.The initial decomposition temperature, peak temperature and exotherm of cycloserine were obtained by dynamic DSC,and the activation energy E and preexponential factor A of cycloserine were obtained by Kissinger method.Furthermore, the self-accelerating decomposition temperature(SADT) of cycloserine was predicted to be 69°C based on the thermodynamic data and the Semenov model, which was verified by the heat accumulation storage test.