癫痫治疗模式的转变:抗癫痫发生和疾病修正治疗

Transformation of epilepsy treatment model:anti-epileptogenesis and disease-modifying therapy

大多数抗癫痫药物不会改变癫痫的病程,基本上是"对症治疗",即使有多种新型抗癫痫药物不断问世,仍有超过30%的患者发展为药物难治性癫痫。因此,寻找新的治疗靶点和开发有效的药物来预防或逆转癫痫发生和进展,是临床和临床前研究的重要目标。基于目前的研究现状,实现抗癫痫发作向抗癫痫发生、疾病修正治疗的转变,不仅需要标准化的动物模型、能够预测癫痫发生或进展的生物标志物,而且需要足够且广泛的受试者群体、严谨的设计方案和前沿的分析方法,使得临床前研究成功向临床转化。毫无疑问,未来以各种神经损伤途径作为靶点来实现癫痫的预防和疾病修正治疗,或可成为治疗及预防癫痫真正有效的手段。

Most anti-seizure medications do not change the course of epilepsy and are basically"symptomatic treatment".Even if a variety of new anti-seizure medications continue to come out,there are still more than 30%of patients develop drug-resistant epilepsy.Therefore,investigating new therapeutic targets and developing effective drugs to prevent or reverse the onset and progression of epilepsy are important goals of clinical and preclinical researches.Based on the current studies,to realize the transformation from anti-seizure to anti-epileptogenesis and disease-modifying therapy,it not only needs standardized animal models and biomarkers that can predict the epileptogenesis or progression but also needs sufficient patients,rigorous design schemes,and cutting-edge analysis methods to successfully transform preclinical research into clinical practice.There is no doubt that in the future,targeting various nerve injury pathways to achieve anti-epileptogenesis and disease-modifying therapy probably becomes a truly effective means of treating and preventing epilepsy.