铁代谢异常与淋巴造血系统肿瘤的研究进展

Research Progress of Abnormal Iron Metabolism and Tumor of Lymphatic Hematopoiesis System——Review

铁代谢是指人体必需微量元素铁在生物体内吸收、转运、储存及转化排泄的过程。正常铁代谢通过各种相关蛋白在系统和细胞水平严密调节铁的含量,以免在铁循环过程中产生过多自由基损害机体。铁代谢异常出现在多种淋巴造血系统肿瘤中,并有研究揭示了其与肿瘤发生发展的隐匿联系。血清铁蛋白水平与铁转运蛋白、转铁蛋白及其受体的异常可作为淋巴造血系统肿瘤的预后指标,且开辟了诊疗的新方向,迄今涌现了大批靶向肿瘤的新型药物。本文简述了正常铁代谢的过程,并在系统水平及细胞水平方面重点阐述了铁代谢异常在淋巴造血系统肿瘤中的研究进展。

Iron metabolism is the process of absorption,transport,storage and conversion and excretion of the essential trace element iron in living organisms.Normal iron metabolism tightly regulates iron content at the systemic and cellular levels through a variety of related proteins to prevent excessive free radicals from being generated during the iron cycle that can damage the body.Various abnormalities in iron metabolism are found in a variety of lympho⁃haematopoietic tumours and an insidious link between iron metabolism and tumour development has been revealed.Serum ferritin levels and abnormalities of iron transport proteins,transferrin and their receptors can be used as prognostic indicators for lymphohematopoietic tumours and have opened up new directions of diagnosis and treatment,with a large number of novel drugs targeting tumours emerging to date.This article briefly describes the normal iron metabolism process and highlights the progress of research on abnormal iron metabolism in lymphohematopoietic tumors at the systemic and cellular levels.