B细胞淋巴瘤IGH基因重排的分子特点及其临床意义

Molecular Characteristics and Clinical Significance of IGH Gene Rearrangement in B-Cell Lymphoma-Review

B细胞淋巴瘤是最常见的恶性淋巴瘤,其发病率有逐年上升趋势,其中一些类型通过形态学及免疫组化常与反应性病变难以区分,亟需其他的辅助诊断方法。由于B细胞淋巴瘤是由已完成IGH重排的B细胞恶变所致,故重排的分子特点可作为鉴别淋巴组织良性增生与恶性增殖的重要参考。随着分子生物学技术的发展,IGH重排的检测在淋巴瘤的诊断、疗效评价及预后评估等方面发挥了重要作用。本文着重阐述IGH克隆性重排在B细胞淋巴瘤中的分子特点及其临床意义。

B-cell lymphoma is the most common malignant lymphoma,and its incidence is increasing year by year.Some types are often indistinguishable from the reactive lesions through morphology combined with immunohistochemistry,so other auxiliary diagnostic methods are urgently needed.Since B-cell lymphoma is caused by malignant transformation of IGH rearranged B cells,the molecular characteristics of rearranged B cells can be used as an important reference for differentiating benign and malignant proliferations of lymphatic tissues.With the development of molecular biology technology,the detection of clonal rearrangement of IGH plays an important role in the diagnosis,efficacy evaluation and prognosis evaluation of lymphoma.This paper focuses on the molecular characteristics and clinical significance of clonal rearrangement of IGH in B-cell lymphoma.