盐酸纳布啡复合丙泊酚用于无痛取卵手术的临床观察

Clinical observation of painless oocyte retrieval with nabuffine hydrochloride combined with propofol

目的:探讨盐酸纳布啡复合丙泊酚静脉麻醉用于无痛取卵术的应用效果及并发症的发生率。方法:选取60例于武汉大学人民医院行无痛取卵手术的患者,随机分为观察组和对照组,观察组静脉注射盐酸纳布啡复合丙泊酚进行麻醉,对照组使用丙泊酚复合芬太尼进行麻醉诱导。观察所有患者术前及术后循环系统(心率、收缩压、舒张压、动脉血氧饱和度)变化情况,记录呼吸抑制发生情况、镇痛效果以及术后不良反应发生率。结果:两组患者术前和术后心率、无创血压和血氧饱和度变化均无明显差异(P>0.05),对照组5例患者发生呼吸抑制,观察组1例患者发生呼吸抑制,与对照组比较,观察组术后苏醒时间、手术时间、术中追加丙泊酚用量、术后30 min视觉模拟量表(VAS)评分、术后头晕、呼吸抑制、恶心呕吐等不良反应发生率降低(P<0.05)。结论:盐酸纳布啡复合丙泊酚静脉麻醉下行无痛取卵术,能有效镇痛并降低术后头晕、呼吸抑制、恶心呕吐等不良反应发生率。

Objective: To investigate the efficacy of intravenous anesthesia of nalbuphine hydrochloride combined with propofol for painless oocyte retrieval and its influence on postoperative cognitive function.Methods: Sixty patients who underwent painless oocyte retrieval surgery were randomly divided into observation group and control group. The observation group was intravenously injected with nalbuphine hydrochloride and propofol for anesthesia, while in control group, propofol combined with fentanyl was used for induction of anesthesia. The changes of circulatory system(heart rate, systolic blood pressure, diastolic blood pressure, and arterial blood oxygen saturation) before and after operation were observed in all patients, and the occurrence of respiratory depression, analgesic effect, and the incidence of postoperative adverse reactions were recorded. Results: There was no significant difference in heart rate, non-invasive blood pressure, and blood oxygen saturation before and after surgery between the two groups(P>0. 05). Five patients in the control group had respiratory depression, while no patients in the observation group had respiratory depression. Compared with the control group, the observation group showed shorter postoperative recovery time and operation time,less intraoperative additional propofol dosage, less postoperative 30 min visual analogue scale(VAS)scores, and lower incidence of adverse reactions such as postoperative dizziness, respiratory depression, nausea and vomiting(P<0. 05). Conclusion: The intravenous anesthesia of nalbuphine hydrochloride combined with propofol can effectively relieve pain and reduce the incidence of adverse reactions such as dizziness, respiratory depression, nausea, and vomiting after operation.