高压氧联合头孢唑林钠对感染性黄疸患儿神经功能及网织红细胞有关参数水平的影响

Effect of Hyperbaric Oxygen Combined with Cefazolin Sodium on Neurological Function and Reticulocyte Related Parameter in Children with Infectious Jaundice

【目的】探讨高压氧联合头孢唑林钠对感染性黄疸患儿神经功能及网织红细胞有关参数水平的影响。【方法】选取2019年2月至2021年4月新乡市中心医院收治的118例感染性黄疸患儿,采用随机数字表法分为观察组和对照组,每组59例。常规治疗基础上,对照组予以头孢唑林钠治疗,观察组予以高压氧联合头孢唑林钠治疗,均治疗7 d。比较两组临床效果、黄疸消退时间、血清总胆红素(TBIL)恢复正常时间、住院时间,治疗前、治疗7 d后血清神经功能有关指标[星形胶质源性蛋白(S100B)、β淀粉样蛋白(Aβ)、神经元特异性烯醇化酶(NSE)]、血清TBIL、网织红细胞有关参数[低核酸网织红细胞比例(L-RTC%)、高荧光网织红细胞比例(H-TC%)、网织红细胞百分比(RET%)],并记录不良反应发生情况。【结果】观察组总有效率为91.53%(54/59),高于对照组的72.88%(43/59),差异有统计学意义(χ^(2)=7.010,P=0.008)。观察组黄疸消退时间、血清TBIL恢复正常时间、住院时间均低于对照组,差异有统计学意义(P<0.05)。治疗7 d后,两组患儿血清S100B、Aβ、NSE、TBIL水平均低于本组治疗前,且观察组低于对照组(P<0.05);两组患儿L-RTC%、RET%均低于治疗前,H-TC%高于治疗前,且两组比较差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】采用高压氧联合头孢唑林钠治疗感染性黄疸患儿可改善患儿神经功能,调节网织红细胞有关参数水平,促进患儿康复,安全有效。

【Objective】To explore the effect of hyperbaric oxygen combined with cefazolin sodium on neurological function and reticulocyte related parameter in children with infectious jaundice.【Methods】A total of 118 children with infectious jaundice in Xinxiang Central Hospital from February 2019 to April 2021 were selected and divided into the observation group and the control group by random number table,with 59 cases in each group.On the basis of conventional treatment,the control group was treated with cefazolin sodium alone,while the observation group was treated with hyperbaric oxygen combined with cefazolin sodium.Patients in both groups received treatment for 7 days.Clinical efficacy,jaundice subsidence time,time for serum total bilirubin(TBIL)to return to normal level,hospitalization time and serum neurological function-related indexes before treatment and 7 days after treatment[Astrocyte-derived protein(S100B),β-amyloid protein(Aβ),Neuron specific enolase(NSE)],TBIL,reticulocyte related parameters[low nucleic acid reticulocyte ratio(L-RTC%),high fluorescent reticulocyte ratio(H-TC%),Reticulocyte percentage(RET%)]level,and the occurrence of adverse reactions were compared between the two groups.【Results】After treatment,the total effective rate in the observation group was 91.53%(54/59),which was higher than 72.88%(43/59)in the control group.The difference was statistically significant(χ^(2)=7.010,P=0.008).The jaundice subsidence time,serum TBIL recovery time,and the hospitalization time in the observation group were shorter than those in the control group(P<0.05).After 7 days of treatment,The serum levels of S100B,Aβ,NSE,and TBIL in the two groups were lower than those before treatment;and the observation group was lower than that of the control group(P<0.05).The levels of L-RTC% and RET% in the two groups were lower than those before treatment,and the levels of H-TC%were higher than those before treatment,and the difference between the two groups was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】The use of hyperbaric oxygen combined with cefazolin sodium in the treatment of children with infectious jaundice can improve the neurological function of the children,adjust the levels of TBIL,WBC,NLR,and reticulocyte related parameters,and promote the recovery of the children.It is safe and effective.