缬沙坦氨氯地平治疗终末期肾病患者的临床疗效及对血清ROCK1、ROCK2水平的影响

Effect of Valsartan and Amlodipine on Serum ROCK1 and ROCK2 Levels in Patients with End-stage Renal Disease

【目的】探讨缬沙坦氨氯地平治疗终末期肾病(ESRD)患者的临床疗效及对血清Rho关联含卷曲螺旋蛋白激酶1(ROCK1)和ROCK2水平的影响。【方法】榆林市第二医院收治的ESRD患者92例,随机分为对照组和观察组,每组46例。两组均给予血液透析治疗,对照组采用氨氯地平,观察组采用缬沙坦氨氯地平降压治疗。比较两组治疗3个月后的疗效,并比较治疗前、治疗3个月后患者血压[收缩压(SBP)、舒张压(DBP)]、肾功能[血清肌酐(SCr)、尿素氮(BUN)]、血清ROCK1、ROCK2水平、生存质量[肾脏病与透析相关生存质量(KDTA)],统计治疗期间不良反应。【结果】观察组总有效率为91.30%(42/46),高于对照组的76.09%(35/46)(P<0.05)。治疗3个月后,观察组DBP、SBP水平,SCr、BUN,血清ROCK1、ROCK2水平均低于对照组(P<0.05)。治疗3个月后,观察组KDTA评分高于对照组(P<0.05)。观察组不良反应总发生率为17.39%(8/46),与对照组的13.04%(6/46)比较,差异无统计学意义(P>0.05)。【结论】缬沙坦氨氯地平治疗ESRD疗效显著,能降低患者血压水平,改善肾功能,降低血清ROCK1、ROCK2水平,提高患者生活质量,且安全性高,临床可推广应用。

【Objective】To study the clinical efficacy of valsartan and amlodipine in the treatment of end-stage renal disease(ESRD)and its effect on the level of serum Rho associated coiled coil protein kinase1(ROCK1)and ROCK2.【Methods】Ninety-two patients with ESRD in Yulin No.2 Hospital were randomly divided into the control group and the observation group,with forty-six cases in each group.Both groups were treated with hemodialysis,in which the control group was treated with amlodipine and the observation group was treated with valsartan and amlodipine.The curative effects of the two groups after 3 months of treatment were compared,and blood pressure level[systolic blood pressure(SBP),diastolic blood pressure(DBP)],the renal function[serum creatinine(SCR),urea nitrogen(BUN)],serum ROCK1 and ROCK2 levels,and quality of life[kidney disease and dialysis related quality of life(KDTA)]before and after 3 months of treatment were compared in both groups.The adverse reactions during treatment were counted as well.【Results】The total effective rate in the observation group was 91.30%(42/46),which was higher than 76.09%(35/46)in the control group(P<0.05).After 3 months of treatment,DBP,SBP,SCr,BUN,and levels of serum ROCK1 and ROCK2 in the observation group were lower than those in the control group(P<0.05).The KDTA score in the observation group after 3 months of treatment was higher than that in the control group(P<0.05).The incidence of adverse reactions was 17.39%(8/46)in the observation group and 13.04%(6/46)in the control group.There was no significant difference between the groups(P>0.05).【Conclusion】Valsartan and amlodipine are effective in the treatment of ESRD.They can lower blood pressure,improve renal function,reduce the levels of serum ROCK1 and ROCK2,improve the quality of life,have high safety,and can be popularized in clinic.