妊娠合并家族性高胆固醇血症的临床特点分析

Clinical characteristics of pregnancy complicated with familial hypercholesterolemia

目的分析家族性高胆固醇血症(FH)患者妊娠时的相关临床特点、治疗方案及妊娠结局,提醒产科医师对此病症高度关注,使患者在疾病早期即能够得到积极、系统的治疗,避免产生严重并发症,保障分娩的安全性。方法对1例年龄33岁的妊娠合并FH的患者进行临床资料、实验室指标及分娩后情况的观察,并复习相关文献。结果患者专科治疗病情无明显好转转入妇产科限期手术分娩,于37^(+2)周行二次子宫下段剖宫产术,术后24 h血脂逐步下降,4 d后出院。结论妊娠合并FH临床上鲜见报道,治疗关键在于早诊断、早治疗,积极降脂预防并发症的发生,适时终止妊娠以获得满意结局。

Objective To analyze the clinical features,treatment options and pregnancy outcomes of patients with familial hypercholesterolemia(FH)during pregnancy.In order to avoid the occurrence of serious complications and improve the delivery safety of the disease,obstetricians′awareness and attention to this disease need to be aroused.Methods Clinical data,laboratory indicators and delivery of a 33 years old pregnant patient with familial hypercholesterolemia were observed,and relevant literature was reviewed.Results After specialized treatment,the condition did not be significantly improved,and she was transferred to our department for surgical delivery within a time limit.The second abdominal and lower uterine cesarean section was performed at 37^(+2) weeks.The blood lipid gradually decreased 24 hours after surgery,and she was discharged after 4 days later.Conclusion Pregnancy with familial hypercholesterolemia is rarely reported clinically.The key of treatment lies in early diagnosis,early treatment,active lipid reduction to prevent complications,and timely termination of pregnancy to achieve a satisfactory outcome.