肠道菌群与妊娠期甲状腺疾病患者的常见不良妊娠结局

Intestinal flora and common adverse pregnancy outcomes in patients with thyroid disease during pregnancy

目前,肠道菌群被认为是影响机体内环境的潜在因素,一旦失调,可能导致多系统的疾病。妊娠期妇女由于机体代谢及免疫状态的变化,是罹患妊娠期甲状腺疾病的高危人群。而妊娠期甲状腺疾病可导致流产、早产和出生体质量过低等常见不良妊娠结局,对产妇、新生儿及其家庭造成十分恶劣的影响。妊娠期妇女作为特殊群体,其肠道菌群的研究备受关注,但目前关于妊娠期甲状腺疾病的肠道菌群研究仍较少。为更好地指导临床以及寻求改善妊娠期甲状腺疾病患者常见不良妊娠结局,本文对肠道菌群与妊娠期甲状腺疾病患者的常见不良妊娠结局的相关研究进行综述。

At present, intestinal flora is regarded as a potential factor affecting the internal environment of the body, and if maladjusted, it may lead to multi-system diseases. Pregnant women are at high risk of developing thyroid disease during pregnancy due to changes in metabolism and immune status. Thyroid diseases during pregnancy can lead to miscarriage, premature delivery, low birth weight and other common adverse pregnancy outcomes, which have a very bad impact on mothers, newborns and their families. Studies on intestinal flora of pregnant women as a special group have attracted much attention, but there are only a few studies on intestinal flora of thyroid diseases during pregnancy. In order to better guide clinical practice and seek new ideas to improve common adverse pregnancy outcomes in patients with thyroid disease during pregnancy, this paper reviewed the intestinal flora and common adverse pregnancy outcomes in patients with thyroid disease during pregnancy.