降钙素原及白细胞介素-6在泛发性脓疱型银屑病53例中的表达及意义

Expression and significance of procalcitonin and IL-6 in 53 cases of generalized pustular psoriasis

目的通过检测降钙素原及白细胞介素(IL)-6在泛发性脓疱型银屑病(GPP)病人血清中的表达水平,为病情和疗效评估寻找标志物。方法收集安徽医科大学第一附属医院2017年1月至2019年12月收治的132例住院银屑病病人的病历资料,入组病人包括寻常型银屑病(PV)46例,红皮病型银屑病(EP)33例,以及GPP 53例,并针对各组病人的年龄、性别和发病年龄等人口学特征以及外周血中降钙素原及IL-6含量进行统计分析。结果治疗前GPP病人的降钙素原、IL-6含量分别为(0.41±0.14)μg/L、(57.75±11.48)ng/L,显著高于PV组的(0.11±0.05)μg/L、(21.76±8.28)ng/L及EP组的(0.14±0.04)μg/L、(32.57±9.39)ng/L(P<0.05)。治疗后GPP病人降钙素原、IL-6水平均明显降低至(0.03±0.01)μg/L、(4.22±1.13)ng/L,较治疗前差异有统计学意义(P<0.05)。ROC分析显示:降钙素原、IL-6及其联合应用对GPP病人病情严重程度的评估有较高价值,其AUC 95%CI分别为0.738(0.569,0.957)、0.787(0.661,0.937)、0.831(0.699,0.988)。结论与其他类型银屑病相比,降钙素原及IL-6在GPP中的表达显著升高,并在治疗后随病情好转下降,可作为GPP的病情和疗效评估标志物。

Objective To detect the expression levels of procalcitonin and interleukin-6(IL-6)in the serum of patients with general-ized pustular psoriasis(GPP)and to find markers for the evaluation of the disease and efficacy.Methods The medical records of 132 inpatients with psoriasis admitted to the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019 were collected,including 46 cases of psoriasis vulgaris(PV),erythroderma 33 cases of psoriasis(EP),and 53 cases of GPP,and the ba-sic characteristics such as age,gender and age of onset of patients in each group,as well as the content of procalcitonin and IL-6 in pe-ripheral blood were statistically analyzed.Results Before treatment,the levels of procalcitonin and IL-6 in the GPP group were(0.41±0.14)μg/L and(57.75±11.48)ng/L,which were significantly higher than those in the PV group[(0.11±0.05)μg/L,(21.76±8.28)ng/L]and EP group[(0.14±0.04)μg/L,(32.57±9.39)ng/L],the difference was statistically significant(P<0.05).After treatment,the levels of procalcitonin and IL-6 in GPP patients were significantly decreased to(0.03±0.01)μg/L and(4.22±1.13)ng/L,and the differences were statistically significant(P<0.05).ROC analysis showed that procalcitonin,IL-6 and their combined application had higher value in eval-uating the severity of GPP patients:AUC 95%CI were 0.738(0.569,0.957),0.787(0.661,0.937)and 0.831(0.699,0.988),respectively.Conclusion Compared with other types of psoriasis,the expressions of procalcitonin and IL-6 in GPP were significantly increased,and decreased with the improvement of the disease after treatment,which can be used as a marker for the evaluation of the disease and efficacy of GPP.