小细胞肺癌损伤分子机制研究进展

Research progress on the injury molecular mechanism of small cell lung cancer injury

肺癌是影响国人健康的重大公共卫生问题。小细胞肺癌(SCLC)是肺癌中占比较小的一种亚型,具有生存率低、预后差等特点。与非小细胞肺癌比较,关于SCLC的研究较为缓慢,很多治疗原则仍依赖于20年前的研究发现。本文对SCLC的背景、概述及流行病学等做一潜在介绍,着重分析SCLC发病损伤机制,包括氧化应激、凋亡、自噬等,并讨论SCLC护理的相关研究进展,分析潜在方向,旨在为SCLC的临床诊治提供参考。

Lung cancer is a major public health problem affecting the health of Chinese people.Small cell lung cancer(SCLC)is a relatively small subtype of lung cancer,with a very low survival rate and poor prognosis.Compared to non-small cell lung cancer,research on SCLC has been slow,and many treatment principles still rely on findings from 20 years ago.This article provides a potential introduction to the background,overview,and epidemiology of SCLC,and focuses on the pathogenesis of SCLC,including oxidative stress,apoptosis,and autophagy.And this article discusss the related research progress of SCLC nursing,analyzes the potential directions,and aim to provide reference for the clinical diagnosis and treatment of SCLC.