清肾灌肠液治疗慢性肾功能衰竭的临床效果

Clinical effect of Qingshen Guanchang Fluid on chronic renal failure

目的研究清肾灌肠液治疗慢性肾功能衰竭的临床效果。方法选取2018年1月至2021年1月安徽省芜湖市中医医院肾内科收治的66例慢性肾功能衰竭患者作为研究对象,根据随机数字表法将其分为对照组和观察组,各33例。对照组采用基础疗法,观察组在对照组的基础上采用清肾灌肠液治疗。比较两组的中医症状评分、肾功能指标、实验室相关指标、临床疗效及不良反应发生情况。结果治疗后两组中医症状评分较治疗前降低,且观察组低于对照组(P<0.01)。治疗后两组血肌酐、尿素氮、尿酸、胱抑素C均较治疗前降低,且观察组低于对照组(P<0.05)。治疗后两组血钙、血磷、血钾均较治疗前降低,且观察组低于对照组(P<0.05)。治疗后,观察组临床疗效优于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论慢性肾功能衰竭患者采用清肾灌肠液治疗安全有效。

Objective To study the clinical efficacy of Qingshen Guanchang Fluid in the treatment of chronic renal failure.Methods A total of 66 patients with chronic renal failure admitted to Department of Nephrology,Wuhu Hospital of Traditional Chinese Medicine from January 2018 to January 2021 were selected as the research objects.They were divided into the control group and the observation group according to the random number table method,with 33 cases in each group.The control group was treated with basic therapy,while the observation group was treated with Qingshen Guanchang Fluid on the basis of the control group.Traditional Chinese medicine symptom scores,renal function indexes,laboratory related indexes,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the scores of traditional Chinese medicine symptoms in the two groups were lower than those before treatment,and that in the observation group was lower than that in the control group(P<0.01).After treatment,the levels of serum creatinine,urea nitrogen,uric acid,and cystatin C in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum calcium,phosphorus,and potassium in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the clinical effect of the observation group was better than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Qingshen Guanchang Fluid is safe and effective in the treatment of chronic renal failure.