新型冠状病毒肺炎患者白介素6的表达水平变化

Changes of IL-6 expression level in patients with new coronavirus pneumonia

目的探讨新型冠状病毒肺炎(COVID-19)患者治疗中白介素6的变化情况。方法选取2020年1月至2020年2月于我院诊治的新冠肺炎患者30例为观察组,另选择同期普通肺炎患者31例为对照组,分析治疗前后两组患者白介素6(IL-6)的变化情况。结果在治疗前IL-6的差异无统计学意义(P>0.05),治疗1 d后,观察组IL-6值开始上升,且高于对照组,差异有统计学意义(P<0.05),治疗后3 d观察组IL-6值出现下降,但仍高于对照组,差异有统计学意义(P<0.05),治疗后7 d观察组IL-6值继续下降,依旧高于对照组,差异有统计学意义(P<0.05)。结论COVID-19患者IL-6水平较普通肺炎患者升高更加显著,且对新冠病毒肺炎患者的早期诊断和治疗有一定的临床价值。

Objective To investigate the changes of interleukin-6 in the treatment of patients with new coronavirus pneumonia.Methods A total of 30 cases of new coronary pneumonia and 31 cases of common pneumonia diagnosed and treated in hospitals from January 2020 to February 2020 were selected to analyze the changes of interleukin-6(IL-6)before and after treatment.Results The differences in the treatment of IL-6 before no statistical significance(P>0.05),1 d after treatment,the observation group of IL-6 value rise significantly,and higher than the control group,the difference had statistical significance(P<0.05),after treatment for 3 d IL-6 values decline in the observation group,and higher than the control group,the difference had statistical significance(P<0.05),7 d after treatment group IL-6 values fell,and higher than the control group,the differences were statistically significant(P<0.05).Conclusion IL-6 level in patients with neocoronavirus pneumonia is significantly higher than that in patients with common pneumonia,and has certain clinical value for early diagnosis and treatment of neocoronavirus pneumonia.