摘要
对COVID-19康复患者健康水平和康复后生活质量的评估是值得关注的重要问题.本研究建立了COVID-19康复者的随访队列,进行问卷调查和血液样本检测,血液指标共55项.参与者为2020年初大流行早期阶段湖北省麻城市的COVID-19患者(n=136),同时纳入对照人群(n=125).康复1年后,60.5%报告至少存在一种不适症状,2年后该比例下降至47.5%.在急性期异常的白细胞、血小板、胆红素等指标,1年后基本恢复正常并在2年随访时保持.部分康复者血红蛋白、肌酐等在1年后异常,但多在2年后恢复.少数康复者肌红蛋白、碱性磷酸酶等指标在康复2年仍未完全恢复正常.本研究结果提示,对于新冠康复者需要合理的健康干预措施和较长的后续行动以促进康复.
作者
林浩
刘雪媛
孙合
张杰
董少波
刘茂顺
李蕾
田金珉
郭雅欣
甘金籼
陈章馥
王鑫
林颖
张丹妮
刘亚宁
张小山
刘培培
徐柯
周翔天
梁浩
高福
刘军
武桂珍
Hao Lin;Xueyuan Liu;Heqiang Sun;Jie Zhang;Shaobo Dong;Maoshun Liu;Lei Li;Jinmin Tian;Yaxin Guo;Jinxian Gan;Zhangfu Chen;Xin Wang;Ying Lin;Danni Zhang;Yaning Liu;Xiaoshan Zhang;Peipei Liu;Ke Xu;Xiangtian Zhou;Hao Liang;George F.Gao;William J.Liu;Guizhen Wu(National Health Commission Key Laboratory of Biosafety,Research Unit of Adaptive Evolution and Control of Emerging Viruses,Chinese Academy of Medical Sciences,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Epidemiology,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;Department of Laboratory Medicine,The Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Macheng Center for Disease Control and Prevention,Huanggang 438300,China;College of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,China;School of Ophthalmology and Optometry,Wenzhou Medical University,Wenzhou 325027,China;Collaborative Innovation Center of Regenerative Medicine and Medical Biological Resources Development and Application,Guangxi Medical University,Nanning 530021,China;CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China)
基金
supported by the National Natural Science Foundation of China(82161148008 and 81971501)
the National Key Research and Development Program of China(2021YFC2301400,2020YFA0708103,and 2021YFC0863300)
the Excellent Young Scientist Program of the National Natural Science Foundation of China(81822040)。