茵栀黄颗粒辅助头孢唑林钠治疗新生儿感染性黄疸疗效

Effect of Yinzhihuang granule combined with cefazolin sodium on treatment of neonates with infectious jaundice

目的 观察茵栀黄颗粒辅助头孢唑林钠治疗新生儿感染性黄疸疗效。方法 选取2018年4月-2020年6月承德医学院附属医院新生儿科收治的感染性黄疸患儿106例,以简单随机化法分为研究组和对照组,每组53例。常规治疗基础上,对照组给予头孢唑林钠,研究组给予茵栀黄颗粒辅助头孢唑林钠,均治疗1周。比较两组临床疗效及治疗前后行为神经评估量表(NBNA)评分、黄疸指数、血清总胆红素(TBil),心肌酶谱指标[肌酸激酶同功酶(CK-MB)、肌酸激酶(CK)、乳酸脱氢酶(LDH)],炎症反应指标[C反应蛋白(CRP)、白细胞计数(WBC)、降钙素原(PCT)],红细胞免疫功能指标[红细胞免疫复合物花环率(RBC-ICR)、红细胞C3b受体花环率(RBC-C3bRR)]水平。结果 研究组治疗1周后总有效率(92.45%)高于对照组(73.58%)(P<0.05);研究组治疗3 d、1周后NBNA评分高于对照组,黄疸指数、血清TBil水平低于对照组(P<0.05);血清CK-MB、CK、LDH、CRP、WBC、PCT及RBC-ICR水平低于对照组,RBC-C3bRR水平高于对照组(P<0.05)。结论 应用茵栀黄颗粒辅助头孢唑林钠治疗感染性黄疸患儿可减轻病情,改善神经发育情况,减轻心肌损伤与炎症反应,提高红细胞免疫功能,提升疗效,且安全性好。

OBJECTIVE To observe the effect of Yinzhihuang granule combined with cefazolin sodium on treatment of neonates with infectious jaundice. METHODS From Apr 2018 to Jun 2020, 106 children with infectious jaundice treated in the neonatal department of the Affiliated Hospital of Chengde Medical College were selected and divided into study group and control group by simple randomization method, with 53 cases in each group. On the basis of conventional treatment, the control group was given cefazolin sodium, and the study group was given cefazolin sodium supplemented by Yinzhihuang granules, both of which were treated for 1 week. The clinical efficacy, neonatal behavioral neurological assessment scale(NBNA) score, jaundice index, serum total bilirubin(TBil), myocardial zymogram indexes [creatine kinase isoenzyme(CK-MB), creatine Kinase(CK), lactate dehydrogenase(LDH)], inflammatory response indexes [C-reactive protein(CRP), white blood cell count(WBC), procalcitonin(PCT)], and erythocyte immune function indicators [Red blood cell immune complex rosette Rate(RBC-ICR), red blood cell C3 b receptor rosette rate(RBC-C3 bRR)] were compared between the two groups before and after treatment. RESULTS The total effective rate of the study group(92.45%) was significantly higher than that of the control group(73.58%)(P<0.05) after 1 week of treatment. The NBNA score of the study group was significantly higher than the control group after 3 days and 1 week of treatment, and the jaundice index and serum total bilirubin levels were significantly lower than those of the control group(P<0.05). The serum CK-MB, CK, LDH, CRP, WBC, PCT and RBC-ICR levels in the study group were significantly lower than those in the control group after 3 days and 1 week of treatment, and the RBC-C3 bRR levels were significantly higher than those in the control group(P<0.05). CONCLUSION Yinzhihuang granules cobined with cefazolin sodium in the treatment of children with infectious jaundice can relieve the condition, improve neurodevelopment, reduce myocardial damage and inflammation, improve red blood cell immune function, improve efficacy, and have good safety.