IgG Fc段受体Ⅰ mRNA和炎症因子对肺部感染诊断的应用价值

Value of IgG Fc segment receptor Ⅰ mRNA and inflammatory factors in diagnosis of lung infection

目的 探讨血清免疫球蛋白G Fc段受体Ⅰ(FCGR1A)的mRNA表达水平,以及白细胞介素-6(IL-6)、降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)表达水平对肺部感染诊断的应用价值。方法 选取2020年1月-2020年9月福建医科大学附属龙岩市第一医院113例肺部感染患者为研究对象,经病原菌培养鉴定,上述研究对象中包括病毒感染组60例,细菌感染组53例,同时选50名健康体检者为对照组,检测血清FCGR1A mRNA表达水平,以及IL-6、PCT、hs-CRP表达水平;接受者操作特征曲线(ROC)评估上述因子对肺部感染患者的诊断价值。结果 三组研究对象血清FCGR1A mRNA、IL-6、PCT及hs-CRP差异有统计学意义(P<0.05),且细菌感染组>病毒感染组>对照组(P<0.05);对照组与病毒感染组,联合检测的曲线下面积(AUC)为0.871;对照组与细菌感染组,联合检测的AUC为0.755;细菌感染组与病毒感染组,联合检测的AUC为0.928;53例细菌感染患者中革兰阴性菌有25例,革兰阳性菌有28例,两组血清FCGR1A mRNA、IL-6、PCT以及hs-CRP比较,无统计学差异。结论 血清FCGR1A mRNA、IL-6、PCT以及hs-CRP对肺部感染患者的临床诊断具有重要的价值,对于治疗方案精准度的提升具有重要的指导意义,为临床提供理论依据。

OBJECTIVE To investigate the expression level of FCGR1 A mRNA and the evaluation value of the expression levels of IL-6, PCT, and hs-CRP in lung infection. METHODS Total of 113 patients with lung infection in Longyan First Hospital affiliated to Fujian Medical University between Jan 2020 and Sep 2020 were recruited as the research subjects. After pathogen culture and identification, the above-mentioned research objects were divided into the viral infection group with 60 cases and the bacterial infection group with 53 cases. Another 50 health examinations during the same period were in the control group. The serum FCGR1 A mRNA expression level, IL-6, PCT and hs-CRP levels were detected. The diagnostic value of the above factors in patients with lung infection were analyzed by ROC assay. RESULTS The differences in serum FCGR1 A mRNA, IL-6, PCT and hs-CRP among the three groups of study objects with lung infection were significant(P<0.05). The indexes in the bacterial infection group were significantly higher than those in the virus infection group, which were also significantly higher than those in the control group. The AUCs of combined detection for the prediction of virus infection and bacterial infection were 0.871 and 0.755. Gram-negative bacteria were detected in 25 of 53 bacterial infection patients, and 28 Gram-positive bacteria were detected. There were no significant differences in serum FCGR1 A mRNA, IL-6, PCT and hs-CRP between the two groups. CONCLUSION Serum FCGR1 A mRNA, IL-6, PCT and hs-CRP are of great value in the clinical diagnosis of patients with lung infection, and can be used to improve the treatment, which may have important guiding significance and provide a theoretical basis for the clinic.