2型糖尿病合并慢性伤口感染患者血清S100A8和S100A9蛋白表达与创面愈合及患者预后的关系

Relationship between expression of serum S100A8,S100A9 proteins and prognosis of type 2 diabetes mellitus patients complicated with chronic wound infection

目的 探讨2型糖尿病合并慢性伤口感染患者血清钙结合蛋白A8(S100A8)、钙结合蛋白A9(S100A9)表达与创面愈合及患者预后的关系。方法 选择2020年1-12月吉林大学第一医院二部内分泌科收治的2型糖尿病合并慢性伤口感染患者60例为研究组,选择同期医院收治2型糖尿病未合并慢性伤口感染患者60例为对照组,比较两组及研究组不同病情严重程度患者S100A8、S100A9创面修复因子血管内皮细胞生长因子(VEGF)、表皮生长因子(EGF)水平,分析指标对预后的评估价值。结果 研究组血清S100A8、S100A9、VEGF、EGF水平高于对照组(P<0.05);随着疾病严重程度的增加,S100A8、S100A9水平逐渐升高(P<0.05);预后较差组出院时血清S100A8、S100A9水平高于预后较好组和完全康复组(P<0.05),预后较好组和完全康复组血清S100A8、S100A9水平比较差异无统计学意义;出院时血清S100A8、S100A9水平预测2型糖尿病合并慢性伤口感染完全康复的曲线下面积分别为0.811和0.853,截断值为69.59 ng/ml和26.52 ng/ml。结论 血清S100A8、S100A9蛋白水平可较为准确反映2型糖尿病合并慢性伤口感染患者病情严重程度,且对于患者出院后1个月的预后有一定预测价值。

OBJECTIVE To explore the relationship between the expression of serum calbindin A8(S100 A8), calbindin A9(S100 A9) proteins and the wound healing and prognosis of the type 2 diabetes mellitus patients complicated with chronic wound infection. METHODS A total of 60 type 2 diabetes mellitus patients complicvated with chroni wound infection who were treated in department of endocrinology of the First Hospital of Jilin University from Jan 2020 to Dec 2020 were assigned as the study group, meanwhile 60 diabetes mellitus patients who were not complicated with chronic wound infection were chosen as the control group. The expression levels of S100 A8, S100 A9, wound repair factors vascular endothelial cell growth factor(VEGF) and epidermal growth factor(EGF) were observed and compared between the two groups and among the patients with different illness condition in the study group, and the values of the indexes in assessment of prognosis were analyzed. RESULTS The levels of serum S100 A8, S100 A9, VEGF and EGF of the study group were significantly higher than those of the control group(P<0.05);the levels of S100 A8 and S100 A9 were significantly elevated with the severity of disease(P<0.05);the levels of serum S100 A8 and S100 A9 of the poor prognosis group were significantly higher than those of the favorable prognosis group and the complete rehabilitation group at the discharge(P<0.05);there were no significant differences in the levels of serum S100 A8 and S100 A9 between the favorable prognosis group and the complete rehabilitation group. The areas under curves of the serum S100 A8 and S100 A9 at the discharge were respectively 0.811 and 0.853 in prediction of complete rehabilitation of the type 2 diabetes mellitus patients complicated with chronic wound infection, and the cutoff values were 69.59 ng/ml and 26.52 ng/ml, respectively. CONCLUSION The serum S100 A8 and S100 A9 proteins may accurately reflect the severity of chronic wound infection in the type 2 diabetes mellitus patients and have certain value in prediction of the prognosis of the patients after the discharge for 1 month.