微流控流体动力聚焦技术制备的脂质体及靶向乳腺癌的新策略

Preparation of Liposomes by Microfluidic Hydrodynamic Focusing Technology and Application in the Treatment of Breast Cancer

脂质体是具有磷脂双分子层结构的囊泡,能够装载多种药物,并在靶向肿瘤的药物递送中具有独特优势,但其在可控制备与靶向效率方面面临重要挑战。本综述聚焦微流控流体动力聚焦制备脂质体的方法,介绍了不同种类的微流控芯片,以及相关过程参数对脂质体性能的影响。另外,着重介绍了脂质体在靶向乳腺癌方面的不同递送策略,为脂质体研究提供一种先进的制备技术与新颖的靶向策略。

Liposomes are vesicles with a phospholipid bilayer structure capable of loading a wide range of drugs and offer unique advantages in targeted tumor drug delivery.However,they face significant challenges in controllable preparation and targeting efficiency.This review focuses on the preparation of liposomes by microfluidic hydrodynamic focusing techniques,introducing different types of microfluidic chips,and the influences of relevant process parameters on liposome properties.Further,different delivery strategies of liposomes for targeting breast cancer are highlighted to provide an advanced preparation technique and novel targeting strategy for liposome research.