基于巨噬细胞的动脉粥样硬化易损斑块靶向成像的研究进展

Advances in molecular imaging by targeting macrophages of atherosclerosis vulnerable plaques

易损斑块破裂是导致急性心脑血管疾病的主要原因之一。巨噬细胞是易损斑块中主要的炎性细胞,与易损斑块的发生、发展及破裂密切相关。对易损斑块的早期诊断及干预能降低急性心脑血管疾病死亡率,而分子影像的发展为早期成像提供了可能。文章对易损斑块中与巨噬细胞相关的分子标志物及目前用于巨噬细胞靶向成像的分子探针进行了综述。

Vulnerable plaque rupture is the leading cause of acute cardiovascular diseases.Macrophages are main inflammatory cells closely related to the rupture of vulnerable plaques.Early diagnosis of vulnerable plaque can reduce the mortality of acute cardiovascular diseases.With the development of molecular imaging,the possibility for early identification of vulnerable plaques may come true.This review summarizes the changes of molecular markers of macrophages in vulnerable plaques and the molecular probes that can target macrophages.