基因治疗性血管生成在下肢缺血性疾病中的研究进展

Research progress of gene-based therapeutic angiogenesis in lower limb ischemia

目的总结基因治疗性血管生成在下肢缺血性疾病治疗中的研究进展,旨在为下肢缺血性疾病的无创治疗提供新的方法。方法收集近年来关于基因治疗性血管生成在下肢缺血性疾病治疗中研究的相关文献并加以综述。结果外周动脉疾病发病率逐年升高,如何有效降低严重下肢缺血患者的截肢率与病死率,仍是当前亟需解决的临床问题。大量国内外基础与临床研究结果表明,基因治疗性血管生成能够有效诱使下肢缺血组织内的血管新生与侧支循环建立,从而改善缺血区域的血流灌注。此外,多种类的新型非病毒类基因递送载体的构建也能在一定程度上提高基因治疗的安全性与有效性。结论基因治疗性血管生成已经取得了十分不错的成果,为下肢缺血性疾病的治疗带来了新的思路与策略,但是仍存有部分问题尚未解决。

Objective To summarize the research progress of gene-based therapeutic angiogenesis in lower limb ischemia,so as to provide a new method for non-invasive treatment of lower limb ischemia.Method The literatures on studies of gene-based therapeutic angiogenesis in lower limb ischemia in recent years were read and reviewed.Results The incidence of peripheral arterial disease had been increasing annually.How to effectively reduce the amputation rate and mortality rate of patients with critical limb ischemia was still a clinical problem that needs to be solved urgently.A large number of basic and clinical studies had shown that gene-based therapeutic angiogenesis could effectively induce angiogenesis and collateral circulation in ischemic tissue of lower limb,leading to the significant improvements of blood perfusion in ischemic areas.Additionally,the construction of many kinds of new non-viral gene delivery vectors could also improve the safety and effectiveness of gene therapy to a certain extent.Conclusion Although promising therapeutic effect of gene-based therapeutic angiogenesis brings new ideas and strategies for the treatment of lower limb ischemia,issues still exist that have not been solved.