类风湿性关节炎和心率变异性的研究进展

Research Progress on Rheumatoid Arthritis and Heart Rate Variability

类风湿关节炎是一种原因不明的慢性炎症性疾病,主要对关节产生影响,会有持续性的高度炎症。迄今为止的多项研究表明,它和多种因素相关。类风湿关节炎病人的心血管发病率和死亡率都显著升高。其中自主神经功能失衡会增加类风湿病人的心血管风险,从而导致类风湿死亡率升高。类风湿的特征之一就是HRV的降低,而HRV的降低又常与心血管风险相互关联。类风湿疾病的早期可能会因为炎症和疼痛,HRV会出现下降,但是随着病程的延长,HRV可能出现上升。但是HRV的使用没有统一的标准,也没有量化,无法反映疾病的严重程度。对H RV进一步的研究,可以多一种心脏功能的评估方法,了解类风湿关节炎对HRV的影响,临床上治疗类风湿关节炎多一个参考指标。

Rheumatoid arthritis is a chronic inflammatory disease of unknown cause,which mainly affects the joints,with persistent high inflammation.A number of studies so far have shown that it is related to a variety of factors.The cardiovascular morbidity and mortality of patients with rheumatoid arthritis have increased significantly.Among them,the imbalance of autonomic nerve function will increase the cardiovascular risk of rheumatoid patients,which will lead to an increase in rheumatoid mortality.One of the characteristics of rheumatoid is the reduction of HRV,and the reduction of HRV is often correlated with cardiovascular risk.In the early stage of rheumatoid disease,HRV may decrease due to inflammation and pain,but as the course of the disease increases,HRV may increase.However,there is no uniform standard for the use of HRV,nor is it quantified,and cannot reflect the severity of the disease.For further research on HRV,there can be one more assessment method of heart function,to understand the impact of rheumatoid arthritis on HRV,and one more reference index for clinical treatment of rheumatoid arthritis.