成人弱视患者自发性脑功能活动异常:一项静息态功能磁共振成像研究

Abnormal spontaneous brain functional activity in adult patients with amblyopia:a resting-state functional magnetic resonance imaging study

弱视是生命早期异常视觉经验导致的视觉发育异常,主要表现为视力缺陷和双眼视功能损害,被认为反映了大脑的发育异常而非眼部的器质性病变。然而,弱视患者功能活动异常的脑区位置及其与临床缺陷的联系尚无定论。本研究旨在分析弱视患者的自发性脑功能活动异常及其与弱视患者视力缺陷和立体视功能缺陷的联系。本研究共纳入31名弱视患者和31名健康对照的静息态功能磁共振成像数据进行分析。结果表明,弱视患者右侧角回、左侧小脑后部和左侧扣带回区域的自发性脑功能活动显著低于正常对照,而右侧颞中回自发性脑功能活动显著高于正常对照。其中,弱视患者左侧小脑的自发性脑功能活动异常与弱视眼最佳矫正视力呈负相关,右侧颞中回的自发性脑功能活动与弱视患者立体视锐度呈正相关。本研究表明,成人弱视患者角回、小脑、颞中回和扣带回的自发性功能活动异常,其中,小脑的自发性功能活动异常减弱与弱视患者的视力缺陷相关,而颞中回自发性功能活动异常增加与弱视患者的立体视缺陷相关。上述发现可能有助于解释弱视的神经机制,从而推动弱视治疗策略的改善。

Amblyopia is a visual development deficit caused by abnormal visual experience in early life,mainly manifesting as defected visual acuity and binocular visual impairment,which is considered to reflect abnormal development of the brain rather than organic lesions of the eye.Previous studies have reported abnormal spontaneous brain activity in patients with amblyopia.However,the location of abnormal spontaneous activity in patients with amblyopia and the association between abnormal brain function activity and clinical deficits remain unclear.The purpose of this study is to analyze spontaneous brain functional activity abnormalities in patients with amblyopia and their associations with clinical defects using resting-state functional magnetic resonance imaging(fMRI)data.In this study,31patients with amblyopia and 31 healthy controls were enrolled for resting-state fMRI scanning.The results showed that spontaneous activity in the right angular gyrus,left posterior cerebellum,and left cingulate gyrus were significantly lower in patients with amblyopia than in controls,and spontaneous activity in the right middle temporal gyrus was significantly higher in patients with amblyopia.In addition,the spontaneous activity of the left cerebellum in patients with amblyopia was negatively associated with the best-corrected visual acuity of the amblyopic eye,and the spontaneous activity of the right middle temporal gyrus was positively associated with the stereoacuity.This study found that adult patients with amblyopia showed abnormal spontaneous activity in the angular gyrus,cerebellum,middle temporal gyrus,and cingulate gyrus.Furthermore,the functional abnormalities in the cerebellum and middle temporal gyrus may be associated with visual acuity defects and stereopsis deficiency in patients with amblyopia.These findings help explain the neural mechanism of amblyopia,thus promoting the improvement of the treatment strategy for amblyopia.